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Documentos Principais

AB1526SP

Sigma-Aldrich

Anti-Nerve Growth Factor-β Antibody

Chemicon®, from rabbit

Sinônimo(s):

NGFbeta

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

reatividade de espécies

chicken, mouse, human, rat

não deve reagir com

bovine

fabricante/nome comercial

Chemicon®

técnica(s)

ELISA: suitable
immunohistochemistry: suitable
western blot: suitable

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

dry ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... NGF(4803)

Especificidade

Nerve growth factor-beta (NGF). Less than 1% cross-reactivity with recombinant human NT3, NT4 and BDNF by ELISA.

Imunogênio

Mouse nerve growth factor-beta purified from salivary glands.

Aplicação

Anti-Nerve Growth Factor-β Antibody detects level of Nerve Growth Factor-β & has been published & validated for use in ELISA, WB, IH.
Immunohistochemistry: 1-2 μg/mL (see suggested protocol).

Immunoblotting: 1-2 μg/mL

Inhibition of biological activity: 1-2 μg/mL
BIOLOGICAL ACTIVITY: This antibody will completely inhibit the survival and neurite outgrowth actions of mouse NGF in chicken dorsal root ganglion neurons in vitro.

ELISA: 1-2 μg/mL

Use neat for in vivo animal studies.

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
Neurochemistry & Neurotrophins

Ligação

Replaces: 04-1119

forma física

Format: Purified
Purified immunoglobulin. Lyophilized from PBS. Contains no preservative. Reconstitute with 500 μL of sterile distilled water (1 mg/mL).

Armazenamento e estabilidade

Maintain at -20 to -70°C in undiluted aliquots for up to one year after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to six months. Avoid repeated freeze/thaw cycles. Glycerol (1:1) may be added for additional stability. Avoid repeated freeze/thaw cycles.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

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Expression of nerve growth factor is upregulated in the rat thymic epithelial cells during thymus regeneration following acute thymic involution.
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Neuropharmacology, 111, 266-282 (2016-09-14)
Nerve growth factor (NGF) holds a pivotal role in brain development and maintenance, been also involved in the pathophysiology of neurodegenerative diseases. Here, we provide evidence that a novel C17-spiroepoxy steroid derivative, BNN27, specifically interacts with and activates the TrkA
Mariana Pehar et al.
Journal of neurochemistry, 89(2), 464-473 (2004-04-02)
Reactive astrocytes frequently surround degenerating motor neurons in patients and transgenic animal models of amyotrophic lateral sclerosis (ALS). We report here that reactive astrocytes in the ventral spinal cord of transgenic ALS-mutant G93A superoxide dismutase (SOD) mice expressed nerve growth
Biochemical effects of antibodies against nerve growth factor on developing and differentiated sympathetic ganglia.
M Goedert et al.
Brain research, 148(1), 264-268 (1978-06-09)

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