N1408
Nerve Growth Factor β Human
>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
Sinônimo(s):
HSAN5, NGF-β human, NGFB, hNGFβ
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About This Item
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Nome do produto
NGF-β human, from human, recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
fonte biológica
human
Nível de qualidade
recombinante
expressed in NSO cells
Ensaio
>97% (SDS-PAGE)
Formulário
lyophilized powder
potência
0.15-3.0 ng/mL ED50/EC50
qualidade
endotoxin tested
embalagem
pkg of 5X0.1 mg
pkg of 0.1 mg
técnica(s)
cell culture | mammalian: suitable
Impurezas
<1 EU/μg
solubilidade
water: soluble 0.1 g/L at 20 °C
nº de adesão UniProt
temperatura de armazenamento
−20°C
Informações sobre genes
human ... NGF(4803)
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Descrição geral
The nerve growth factor β (NGFB) gene is mapped to human chromosome 1p13.2.
Aplicação
NGF-β human has been used:
- in protein pin arrays
- to induce U87-MG (glioblastoma cell line) cell proliferation
- in drug release kinetics
Ações bioquímicas/fisiológicas
Nerve growth factor β (NGFB) acts as a key mediator in neuronal and non-neuronal development, differentiation, and survival. Polymorphism of NGFB gene leads to hereditary sensory and autonomic neuropathies. Charcot arthropathy and thermal insensitivity are few of the related symptoms. NGFβ is known to promote cancer cell proliferation and metastasis, also mediates angiogenesis. It facilitates the development of various cancer including, oral, breast, lungs, pancreatic and prostate cancers. Elevated expression of NGFβ contributes to progression of human cholangiocarcinoma. In animal models, NGFβ is observed to prevent cholinergic neuron loss and enhances memory. NGF-β promotes the survival and cholinergic phenotype of basal forebrain cholinergic neurons and stimulates neurite outgrowth of embryonic trigeminal motor neurons in vitro.
forma física
Lyophilized from 0.2% acetic acid containing 5 mg bovine serum albumin.
Nota de análise
The biological activity is measured in a cell proliferation assay using a factor-dependent human erythroleukemic cell line, TF-1.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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K A Crutcher et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 13(6), 2540-2550 (1993-06-01)
A two-site ELISA and a bioassay were used to detect NGF-like activity in human brain tissue. Both assays detected mouse NGF and recombinant human NGF with approximately equal sensitivity, whereas the antibodies showed little cross-reactivity with the recombinant human proteins
Nerve Growth Factor Stimulates Glioblastoma Proliferation through Notch1 Receptor Signaling
Park JC, et al.
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S Korsching
The Journal of neuroscience : the official journal of the Society for Neuroscience, 13(7), 2739-2748 (1993-07-01)
The neurotrophic factor concept in its basic form envisages that innervated tissues produce a signal for the innervating neurons for the selective limitation of neuronal death occurring during development (Purves, 1986; Oppenheim, 1991). This concept arose several decades ago on
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