N2513
Nerve Growth Factor β rat
≥97% (SDS-PAGE), recombinant, expressed in Sf21 cells, lyophilized powder, suitable for cell culture
Sinônimo(s):
NGF-β from rat, Nerve Growth Factor-β from rat
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About This Item
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Nome do produto
NGF-β from rat, recombinant, expressed in Sf21 cells, lyophilized powder, suitable for cell culture
fonte biológica
rat
Nível de qualidade
recombinante
expressed in Sf21 cells
Ensaio
≥97% (SDS-PAGE)
Formulário
lyophilized powder
potência
0.15-3.00 ng/mL EC50
embalagem
pkg of 0.1 mg
técnica(s)
cell culture | mammalian: suitable
Impurezas
endotoxin, tested
solubilidade
water: soluble 0.1 g/L at 20 °C
nº de adesão UniProt
temperatura de armazenamento
−20°C
Informações sobre genes
rat ... NGF(4803)
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Descrição geral
NGFβ (nerve growth factor β) is a protein involved in signal transduction, and expressed by multiple tissues such as placenta, urothelium and bladder smooth muscle cells. It is a neurotrophin and belongs to the NGF family.
Aplicação
NGF-β from rat is used for the following applications:
- In the preparation of DMEM medium (for the cultivation and differentiation of PC12 cells)
- Western blotting analysis
- For the preparation of differentiation medium (it is prepared from DMEM, in which NGF-β is one of the components)
- In cell culture and treatment (for neuronal differentiation)
- In the preparation of stock solution
Ações bioquímicas/fisiológicas
NGFβ (nerve growth factor β) is essential for the differentiation and survival of neurons. It also plays a key role in the development and maintenance of nervous system. It is also involved in angiogenesis, and facilitates tumorigenesis such as, oral, breast and prostate cancers. It has potential as marker for the diagnosis of interstitial cystitis/painful bladder syndrome (IC/PBS) and overactive bladder (OAB), and might also aid in determining the therapy for the same. It might be involved in changes in placental function, as NGF signaling is influenced by antenatal depression and selective serotonin reuptake inhibitor (SSRI) treatment.
forma física
Lyophilized from a 0.2 μm filtered solution in PBS and 1 M NaCl containing 50 μg of bovine serum albumin per 1 μg of cytokine
Nota de análise
The biological activity is measured in a cell proliferation assay using the factor-dependent human erythroleukemic cell line, TF-1.
Código de classe de armazenamento
13 - Non Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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