L4129
L-α-Lysophosphatidylcholine from egg yolk
≥99%, Type I, powder
Sinônimo(s):
1-Acyl-sn-glycero-3-phosphocholine, L-α-Lysolecithin
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About This Item
Produtos recomendados
fonte biológica
egg yolk
Nível de qualidade
descrição
zwitterionic
tipo
Type I
Ensaio
≥99%
Formulário
powder
cor
white
grupo funcional
phospholipid
tipo de lipídio
phosphoglycerides
Condições de expedição
ambient
temperatura de armazenamento
−20°C
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Aplicação
L-α-Lysophosphatidylcholine from egg yolk has been used:
- as a surfactant
- as a media supplement and in Staphylococcus aureus inhibition assay in dermatitis
- as a demyelinating agent for nerve
- as a component in sperm nuclei preparation buffer
Ações bioquímicas/fisiológicas
Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun.
Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na+ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K+ channels.
Qualidade
Contains primarily palmitic and stearic acids.
Nota de preparo
Prepared by the action of phospholipase A on egg L-α-phosphatidylcholine.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Christopher E McMurran et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(50), 25311-25321 (2019-11-20)
The microbiota is now recognized as a key influence on the host immune response in the central nervous system (CNS). As such, there has been some progress toward therapies that modulate the microbiota with the aim of limiting immune-mediated demyelination
Lauri J Lehto et al.
Frontiers in neuroscience, 11, 433-433 (2017-08-22)
In this work a new MRI modality entitled Relaxation Along a Fictitious Field in the rotating frame of rank 4 (RAFF4) was evaluated in its ability to detect lower myelin content in lysophosphatidyl choline (LPC)-induced demyelinating lesions. The lesions were
Isolation and demembranation of Xenopus sperm nuclei
Hazel JW and Gatlin JC
Cold Spring Harbor Protocols (2018)
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de Vito G, et al.
Optics Express, 22(11), 13733-13743 (2014)
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