G1404

Glutathione reduced ethyl ester

≥90% (TLC)

• Sinônimo(s): γ-Glu-Cys-Gly-OEt, GSH-MEE
• Fórmula empírica (Notação de Hill): C₁₂H₂₁N₃O₆S
• Número CAS: 92614-59-0
• Peso molecular: 335.38
• Número MDL: MFCD00156117
• Código UNSPSC: 12161504
• ID de substância PubChem: 329799840
• NACRES: NA.26

Propriedades

• product name: Glutathione reduced ethyl ester, ≥90% (TLC)
• Ensaio: ≥90% (TLC)
• forma: powder
• cor: white to off-white
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CCOC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O
• InChI: 1S/C12H21N3O6S/c1-2-21-10(17)5-14-11(18)8(6-22)15-9(16)4-3-7(13)12(19)20/h7-8,22H,2-6,13H2,1H3,(H,14,18)(H,15,16)(H,19,20)/t7-,8-/m0/s1
• chave InChI: JKRODHBGNBKZLE-YUMQZZPRSA-N

Descrição

Amino Acid Sequence

Glu-Cys-Gly-OEt

Aplicação

Glutathione reduced ethyl ester has been used:

• to increase intracellular glutathione levels in mouse fibroblast L929 cells
• as a medium supplement in Spodoptera frugiperda (Sf)9 cells
• to evaluate its effect on lipid peroxidation after spinal cord injury

Ações bioquímicas/fisiológicas

Glutathione reduced ethyl ester (GSH-MEE) is a membrane/lipid permeable derivative of GSH that may be used to partially supplement the GSH supply within cells subjected to cysteine and/or GSH depletion. GSH-MEE is hydrolysed by intracellular esterases to release GSH, thereby increases the concentrations of intracellular GSH. It prevents the toxic effects of acetaminophen in animal cells. It protects human lymphoid cells and skin fibroblasts against the damage caused due to radiation.

Glutathione reduced ethyl ester inhibits melanin synthesis by inhibiting tyrosinase activity in Melan-A cells. Its antimelanogenic functionality has potential in treating hyperpigmentation skin disorders. GEE supplementation during islets isolation form pancreas reduces reactive oxygen species production and apoptosis.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)