I1636
Anti-Human IgM (μ-chain specific) antibody produced in goat
whole antiserum
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About This Item
Produtos recomendados
fonte biológica
goat
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
whole antiserum
tipo de produto de anticorpo
secondary antibodies
clone
polyclonal
contém
15 mM sodium azide
técnica(s)
indirect ELISA: 1:100,000
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
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Descrição geral
Immunoglobulin M (IgM) is the major component of antibodies. It is the first antibody to be secreted during a primary antibody response, which is expressed in the human fetus. IgM is produced by B1 cells, which is found in blood.
Especificidade
The antibody preparation is specific for human IgM when tested against purified human IgA, IgG, Bence Jones Kappa and Bence Jones Lambda light chains
Ações bioquímicas/fisiológicas
IgM antibodies are present as pentamers in the serum and are produced in response to antigens.
Immunoglobulin M (IgM) pentamer activates the classical pathway of complement activation and lysis of red blood cells. Monoclonal IgM antibodies provides protection against systemic infection and autoimmune diseases. It does not cross human placenta. IgM regulates B cell development.
forma física
Supplied as a liquid containing 15 mM sodium azide as a preservative.
Armazenamento e estabilidade
For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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The Journal of Experimental Medicine, 122(6), 1173-1188 (1965)
Role of natural and immune IgM antibodies in immune responses
Boes M, et al.
Molecular Immunology, 37(18), 1141-1149 (2000)
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E J Wiersma et al.
Journal of immunology (Baltimore, Md. : 1950), 160(12), 5979-5989 (1998-06-24)
Previous studies have discerned two forms of polymeric mouse IgM: moderately cytolytic (complement-activating) pentamer, which contains J chain, and highly cytolytic hexamer, which lacks J chain. To investigate the relationships among polymeric structure, J chain content, and cytolytic activity, we
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