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H0163

Sigma-Aldrich

Anti-Histone Deacetylase 4 (HDAC4) antibody, Mouse monoclonal

enhanced validation

clone HDAC4-144, purified from hybridoma cell culture

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About This Item

Número MDL:
MFCD05665442
Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

mouse

conjugado

unconjugated

forma do anticorpo

purified from hybridoma cell culture

tipo de produto de anticorpo

primary antibodies

clone

HDAC4-144, monoclonal

Formulário

buffered aqueous solution

peso molecular

antigen ~140 kDa

reatividade de espécies

human, rat, mouse

validação aprimorada

independent
Learn more about Antibody Enhanced Validation

concentração

~2 mg/mL

técnica(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 1-2 μg/mL using total cell extracts of NIH3T3 fibroblasts cells

Isotipo

IgG2a

nº de adesão UniProt

P56524

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... HDAC4(9759)
mouse ... Hdac4(208727)
rat ... Hdac4(363287)

Descrição geral

Monoclonal Anti-Histone Deacetylase 4 (HDAC4) (mouse IgG2a isotype) is derived from the HDAC4-144 hybridoma produced by the fusion of mouse myeloma cells (NS1) and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to amino acids of human HDAC4 with C-terminal added lysine, conjugated to KLH. HDAC4 belongs to the class II of Mammalian HDACs.

Aplicação

Anti-Histone Deacetylase 4 (HDAC4) antibody, Mouse monoclonal has been used in:
  • enzyme linked immunosorbent assay (ELISA)
  • immunoblotting
  • immunocytochemistry
  • immunoprecipitation

Ações bioquímicas/fisiológicas

Histone deacetylase (HDAC) catalyzes the deacetylation of histones. HDAC4 is implicated in transcriptional repression. It dynamically migrates between nucleus and cytoplasm through its nuclear import and export signals. Interaction of HDAC4 with 14-3-3 and myocyte enhancer factor-2 (Mef2) proteins disturbs such shuttling and thus directs HDAC4 to the cytoplasm and the nucleus, respectively.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
087M4842V
067M4766V
083M4763
013M4779
073K4874

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Erasers of Histone Acetylation: The Histone Deacetylase Enzymes
Seto E, et al.
Cold Spring Harbor Perspectives in Biology, 6 (2014)
Pan Luo et al.
Brain research bulletin, 156, 50-57 (2020-01-11)
Cerebral ischemia-reperfusion (I/R) can trigger neuronal death through several biologically plausible pathways, but its underlying neurobiological mechanisms remain unclear. In this study, we tested whether hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) is altered in I/R that contributes to neuron damage
Yali Kong et al.
Molecular cancer therapeutics, 10(9), 1591-1599 (2011-06-24)
Inhibitors of histone deacetylases (HDAC) are an important emerging class of drugs for the treatment of cancers. HDAC inhibitors are currently under evaluation in clinical trials as single agents and as sensitizers in combinations with chemotherapies and radiation therapy. Although
Histone deacetylase 4 possesses intrinsic nuclear import and export signals
Wang AH, et al.
Molecular and Cellular Biology, 21, 5992-6005 (2001)
Chi Ma et al.
The Journal of biological chemistry, 286(6), 4819-4828 (2010-12-02)
Histone deacetylase (HDAC) 7 is a member of the HDAC family of deacetylases. Although some of the HDAC proteins have been shown to regulate neuronal survival and death, whether HDAC7 has a similar role is not known. In this study
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