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Key Documents

H8283

Sigma-Aldrich

Hemocyanin from Megathura crenulata (keyhole limpet)

PBS solution

Sinônimo(s):

KLH, Keyhole limpet hemocyanin

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About This Item

Número CAS:
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.25

fonte biológica

Megathura crenulata

Nível de qualidade

forma

PBS solution

concentração

3.0-7.0 mg/mL protein (A280)

teor de cobre

0.10-0.30% (based on protein)

técnica(s)

ELISA: suitable

temperatura de armazenamento

2-8°C

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Descrição geral

Gastropod hemocyanins are massive glycoproteins (4 to 8 MDa) designed by an intricate arrangement of 10 subunits that are self-assembled into hollow cylinders 35 nm in diameter.
Hemocyanin is a high molecular weight copper containing glycoprotein. It reversibly binds oxygen and forms the extra-cellular respiratory protein of mollusks. Keyhole limpet hemocyanin (KLH) is filtered from the hemolymph of Megathura crenulata, also called the giant keyhole limpet. It is native to the southern California coast and Mexico.

Aplicação

Keyhole limpet hemocyanin (KLH) is a strong and well known immune-stimulant in both experimental animals and humans. It has been used as a hapten carrier protein to enhance antigen-specific T cell priming and is known to stimulate a CD4+ T-cell response.
Hemocyanin was used to study if antipeptide antibodies specifically recognize the l1 protein of the human papilloma virus of type 31. It was also used to study the acid-induced unfolding of didecameric keyhole limpet hemocyanin.

forma física

Solution in PBS, pH 7.2, containing 1mM CaCl2 and 0.5 mM MgCl2 with 15 mM sodium azide as preservative

Nota de preparo

Chromatographically purified.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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