G6752

Guanosine

≥98%

• Sinônimo(s): 9-(β-D-Ribofuranosyl)guanine, Guanine-9-β-D-ribofuranoside
• Fórmula empírica (Notação de Hill): C₁₀H₁₃N₅O₅
• Número CAS: 118-00-3
• Peso molecular: 283.24
• Beilstein: 625911
• Número CE: 204-227-8
• Número MDL: MFCD00010182
• Código UNSPSC: 41106305
• ID de substância PubChem: 24895268
• NACRES: NA.51

Propriedades

• fonte biológica: microbial
• Nível de qualidade: 100; 200
• Ensaio: ≥98%
• forma: powder
• pf: 250 °C (dec.) (lit.)
• solubilidade: formic acid:water (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• cadeia de caracteres SMILES: [H]O[H].NC1=Nc2c(ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1
• InChI: 1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
• chave InChI: NYHBQMYGNKIUIF-UUOKFMHZSA-N

Descrição

Descrição geral

Guanosine is an aromatic organic molecule and a purine nucleoside. It is present in the cerebrospinal fluid, intestinal cells, blood-brain barrier and in brain microvessels.

Aplicação

Guanosine has been used:

• as a reference standard for the analysis of glucosinolates by high-performance liquid chromatography with diode-array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI/MS)
• as a component of Mouse Embryonic Fibroblasts (MEFs) culture
• as a standard for the detection of residual RNA contaminant in oil palm plant genome samples by HPLC

Ações bioquímicas/fisiológicas

Guanosine nucleoside elicits cellular effect as the guanine-based purinergic system. It modulates glutamate uptake by glutamate transporters. It may have neuroprotective functionality in central nervous system disorders. Guanosine promotes neurite arborization, outgrowth, proliferation and differentiation. Administration of guanosine replenished GTP and elicits protective function in renal ischemic injury.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges