F4883
Fibrinogênio
35-65% protein (≥90% of protein is clottable).
Sinônimo(s):
Fator I
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About This Item
Produtos recomendados
fonte biológica
human plasma
Nível de qualidade
descrição
essentially plasmin(ogen) free
forma
powder
qualidade
35-65% protein (≥90% of protein is clottable).
peso molecular
α-chain 63.5 kDa
β-chain 56 kDa
γ chain 47 kDa (about 4% carbohydrate content)
soluble dimer 340 kDa
concentração
35-65% protein (biuret)
técnica(s)
cell culture | mammalian: suitable
solubilidade
0.9% NaCl: soluble
temperatura de armazenamento
−20°C
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Descrição geral
Fibrinogen was the first blood coagulation factor to be identified, and it is a precursor of fibrin protein. This protein is composed of two chains, each of which is composed of three chains- α, β and γ. These three subunits are coded by three genes located in the human chromosomal locus 4q23-q32, and spans 51kb.
Aplicação
Fibrinogen from human plasma has been used for-
- fibrinogen adsorption assay performed on swCNTs (single-walled carbon nanotubes)
- the characterization of fibrinogen structure in the presence of CNT using CD (Circular dichroism) spectroscopy and temperature scan
- the preparation of RBC suspension obtained from venous blood of antecubital vein, to assess RBC aggregability
- fibrinolysis assay performed on mouse embryonic fibroblasts (MEFs)
- the preparation of fibrinogen-labeled gold (Fgn/Au)
- the quantification of in vitro angiogenesis by human microvascular endothelial cells and
- the assessment of fibrin-induced apoptosis and differentiation-regulation in trophoblast obtained from term human placentas.
Ações bioquímicas/fisiológicas
O fibrinogênio é uma proteína de fase aguda que faz parte da cascata de coagulação de proteínas. O resultado final da cascata é a produção de trombina, que converte fibrinogênio em fibrina. A trombina proteolisa rapidamente o fibrinogênio, liberando o fibrinopeptídeo A. A perda desse pequeno peptídeo não é suficiente para tornar a molécula de fibrina resultante insolúvel, mas tende a formar complexos com as moléculas adjacentes de fibrina e fibrinogênio. Em seguida, a trombina cliva da fibrina um segundo peptídeo, o fibrinopeptídeo B, e, então, os monômeros de fibrina formados se polimerizam espontaneamente para formar um gel insolúvel. A fibrina polimerizada é mantida íntegra por forças não covalentes e eletrostáticas e estabilizada pela enzima de transamidação, fator XIIIa, que é produzida pela ação da trombina sobre o fator XIII. Os agregados insolúveis de fibrina (coágulos) e as plaquetas agregadas bloqueiam, então, o vaso sanguíneo danificado e impedem sangramento adicional. A quantidade de fibrinogênio no plasma pode funcionar como um indicador não específico da presença ou ausência de um processo inflamatório no organismo. O fibrinogênio originário de qualquer mamífero será clivado por uma trombina originária de qualquer mamífero.
Fibrinogen is an acute-phase inflammatory protein, which plays an essential role in blood clotting. Coronary heart disease is linked to the plasma levels of fibrinogen in Chinese population, and might have potential as a marker and risk factor for the same. A -455 allele of fibrinogen β (FGB) chain is linked with poor survival in Caucasian women with Finnish stroke. Ischemic stroke preceded by hyperfibrinogenemia has poor outcome, which is independent of the baseline fibrinogen concentration.
Especificações
Source material has tested negative for HIV and HBsAg.
forma física
Lyophilized powder containing sodium citrate and sodium chloride.
Nota de análise
Protein determined by biuret
Exoneração de responsabilidade
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
Certificados de análise (COA)
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Marta Swarowska et al.
Inflammation, 37(4), 1142-1147 (2014-02-18)
Hyperfibrinogenemia at the beginning of ischemic stroke is associated with poor outcome. We hypothesized that the sustained increase of plasma fibrinogen during stroke predicts outcome independently of baseline fibrinogen concentration. We included 266 patients with first-ever ischemic stroke in whom
Bin Song et al.
International journal of clinical and experimental medicine, 8(8), 13195-13202 (2015-11-10)
Coronary heart disease (CHD) remains the leading causes of death and disability for men and women in most developed countries. It may soon become the leading cause of death in developing countries. Several studies have examined the role of fibrinogen
J G White
The American journal of pathology, 137(4), 989-998 (1990-10-01)
Glycoprotein (GP)IIb-IIIa receptors on human platelets in suspension and after surface activation bind a variety of specific antibodies and ligands and transport them across the outside of the plasma membrane by processes of clustering, patching and capping, and endocytosis to
A synergistic effect of albumin and fibrinogen on immunoglobulin-induced red blood cell aggregation.
Ronen Ben-Ami et al.
American journal of physiology. Heart and circulatory physiology, 285(6), H2663-H2669 (2003-07-19)
Therapeutic administration of immunoglobulins (Ig) has the potential to precipitate thrombotic events. This phenomenon may be explained by red blood cell (RBC) aggregation, which can be potentiated by Ig. The contribution of plasma albumin and fibrinogen to Ig-induced RBC aggregation
Sung Jean Park et al.
International journal of nanomedicine, 7, 4325-4333 (2012-08-24)
The conformational changes of plasma protein structures in response to carbon nanotubes are critical for determining the nanotoxicity and blood coagulation effects of carbon nanotubes. In this study, we identified that the functional intensity of carboxyl groups on carbon nanotubes
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