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C7971

Sigma-Aldrich

Cilostamide

phosphodiesterase inhibitor

Sinônimo(s):

6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one, OPC 3689

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About This Item

Fórmula empírica (Notação de Hill):
C20H26N2O3
Número CAS:
68550-75-4
Peso molecular:
342.43
Número MDL:
MFCD00673958
Código UNSPSC:
12352202
ID de substância PubChem:
24278337
NACRES:
NA.77

Ensaio

≥97% (HPLC)

forma

powder

solubilidade

DMSO: 20 mg/mL, clear, colorless to faintly yellow

cadeia de caracteres SMILES

CN(C1CCCCC1)C(=O)CCCOc2ccc3NC(=O)C=Cc3c2

InChI

1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)

chave InChI

UIAYVIIHMORPSJ-UHFFFAOYSA-N

Informações sobre genes

human ... PDE3A(5139) , PDE3B(5140) , PDE5A(8654) , PDE7A(5150)
rat ... Pde2a(81743) , Pde4a(25638)

Ações bioquímicas/fisiológicas

PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and vasodilatory. They are being recognized for its use in treating heart failures. Cilostamide is known to delay meiotic progression.
Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC50 = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Gang Feng et al.
Science translational medicine, 3(83), 83ra40-83ra40 (2011-05-20)
Regulatory T cells (T(regs)) manipulated ex vivo have potential as cellular therapeutics in autoimmunity and transplantation. Although it is possible to expand naturally occurring T(regs), an attractive alternative possibility, particularly suited to solid organ and bone marrow transplantation, is the
L Vanhoutte et al.
Human reproduction (Oxford, England), 24(8), 1946-1959 (2009-04-28)
Controlling nuclear maturation during oocyte culture might improve nuclear-cytoplasmic maturation synchrony. In the present study, the quality of mouse and human cumulus-enclosed oocytes (CEOs) was examined after a two-step culture consisting of a three-dimensional prematuration culture (3D-PMC), followed by in
K M Tang et al.
European journal of pharmacology, 268(1), 105-114 (1994-06-15)
Ultraviolet irradiation of human platelet cytosol in the presence of 32P-labelled cyclic GMP (cGMP) can specifically label 110, 80, 55, 49 and 38 kDa proteins; the 110 kDa species is the subunit of cGMP-inhibited phosphodiesterase (PDE III) and the 80
Alberto M Luciano et al.
Biology of reproduction, 85(6), 1252-1259 (2011-08-06)
Oocyte development is characterized by impressive changes in chromatin structure and function in the germinal vesicle (GV) that are crucial in conferring to the oocyte meiotic and developmental competence. During oogenesis, oocyte and follicular cells communicate by paracrine and junctional
F K Albuz et al.
Human reproduction (Oxford, England), 25(12), 2999-3011 (2010-09-28)
Oocyte in vitro maturation (IVM) reduces the need for gonadotrophin-induced ovarian hyperstimulation and its associated health risks but the unacceptably low conception/pregnancy rates have limited its clinical uptake. We report the development of a novel in vitro simulated physiological oocyte
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