C3535
Complement C8 from human serum
suitable for radioiodination, RIA, ≥85% (SDS-PAGE), ≥125,000 C8H50 units/mg protein (using C8 deficient serum)
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About This Item
Produtos recomendados
fonte biológica
human
Nível de qualidade
Ensaio
≥85% (SDS-PAGE)
forma
solution
atividade específica
≥125,000 C8H50 units/mg protein (using C8 deficient serum)
concentração
1 mg/mL in PBS, pH 7.2
técnica(s)
immunoelectrophoresis: suitable
adequação
suitable for radioiodination, RIA
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... C8A(731)
Categorias relacionadas
Aplicação
Complement C8 is one of the end terminals of the complement system contained in the membrane attack complex (MAC). In the (MAC), C8 initiates and coordinates MAC pore formation. It has been used in research to investigate the mechanisms of how C8-C9 and C9-C9 interactions facilitate folding of the membrane attack complex perforin (MACPF) domain to form the circular pore.
Ações bioquímicas/fisiológicas
C8 is one of the components of the terminal complement complex and is required for a functional complement system. It is composed of disulfide-linked C8α and C8γ and a noncovalently associated C8β chain. During formation of the membrane-attack complex, a domain on C8α induces C9 to polymerize and form a pore-like structure.
Qualidade
Functionally pure by a sensitive hemolytic assay using depleted sera.
Outras notas
View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer
Exoneração de responsabilidade
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Daniel J Slade et al.
Biochemistry, 45(16), 5290-5296 (2006-04-19)
Human C8 is one of five components of the membrane attack complex of complement (MAC). It contains three subunits (C8alpha, C8beta, C8gamma) arranged as a disulfide-linked C8alpha-gamma dimer that is noncovalently associated with C8beta. C8alpha, C8beta, and complement components C6
Leslie L Lovelace et al.
The Journal of biological chemistry, 286(20), 17585-17592 (2011-04-02)
C8 is one of five complement proteins that assemble on bacterial membranes to form the lethal pore-like "membrane attack complex" (MAC) of complement. The MAC consists of one C5b, C6, C7, and C8 and 12-18 molecules of C9. C8 is
Doryen Bubeck et al.
Journal of molecular biology, 405(2), 325-330 (2010-11-16)
Complement component C8 plays a pivotal role in the formation of the membrane attack complex (MAC), an important antibacterial immune effector. C8 initiates membrane penetration and coordinates MAC pore formation. High-resolution structures of C8 subunits have provided some insight into
Zhexu Chi et al.
Molecular cell, 80(1), 43-58 (2020-09-17)
Immune cell function depends on specific metabolic programs dictated by mitochondria, including nutrient oxidation, macromolecule synthesis, and post-translational modifications. Mitochondrial adaptations have been linked to acute and chronic inflammation, but the metabolic cues and precise mechanisms remain unclear. Here we
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