C3045

Colesterol

powder, BioReagent, suitable for cell culture, ≥99%

• Sinônimo(s): 3β-Hidroxi-5-colesteno, 5-Colesteno-3β-ol
• Fórmula empírica (Notação de Hill): C₂₇H₄₆O
• Número CAS: 57-88-5
• Peso molecular: 386.65
• Beilstein: 1915888
• Número CE: 200-353-2
• Número MDL: MFCD00003646
• Código UNSPSC: 12352211
• eCl@ss: 39023139
• ID de substância PubChem: 24892329
• NACRES: NA.75

Propriedades

• fonte biológica: ovine wool
• Nível de qualidade: 200
• linha de produto: BioReagent
• Ensaio: ≥99%
• forma: powder
• técnica(s): cell culture | mammalian: suitable
• pb: 360 °C (lit.)
• pf: 147-149 °C (lit.)
• solubilidade: H₂O: 0.002 mg/mL; Tween: soluble; ethanol: soluble; serum: soluble
• densidade: 1.067 g/mL at 25 °C (lit.)
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
• chave InChI: HVYWMOMLDIMFJA-DPAQBDIFSA-N
• Informações sobre genes: human ... POLA1(5422) , TOP2A(7153) ; rat ... Ar(24208) , Polb(29240)

Descrição

Descrição geral

Cholesterol, a major sterol is the precursor for steroid hormones, bile acid and vitamin in mammals and coordinates endocytosis. It complexes with protein to form lipoproteins for transport in blood. It exists either as high-density lipoprotein (HDL) or low-density lipoprotein (LDL). HDL also called good cholesterol has less lipid content. LDL or bad cholesterol has high lipid content. Statin inhibition of HMG-CoA reductase enzyme in the cholesterol biosynthesis pathway controls elevated cholesterol levels in atherosclerosis and hypercholesterolemia. Low levels of cholesterol results in hypothyroidism, familial hypobetalipoproteinemia and liver disease. Imbalance of cholesterol homeostasis and intracellular cholesterol levels play a key role in cancer development. High cholesterol levels favor breast cancer progression.

Aplicação

Cholesterol has been used:

• as a medium supplement in chorionic villous tissue culture form placenta
• as a component of hormone pellet for implantation in mice ovary
• for inducing expression of immunity-related GTPase M (IRGM) in human monocytic cell line, THP-1

Ações bioquímicas/fisiológicas

Componente importante de todas as membranas biológicas; cerca de 25% do teor total de lipídios no cérebro é de colesterol.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)