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L8039

Sigma-Aldrich

Lipoprotein, high density from human plasma

≥95% (SDS-PAGE), solution

Sinônimo(s):

α-Lipoprotein, HDL, High density lipoprotein

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About This Item

Número CAS:
308068-14-6
Número MDL:
MFCD00164407
Código UNSPSC:
12352211
NACRES:
NA.25

fonte biológica

human plasma

Nível de qualidade

200

Ensaio

≥95% (SDS-PAGE)

forma

solution

embalagem

vial of 10 mg protein

técnica(s)

cell culture | mammalian: suitable

nº de adesão UniProt

P02649
P02655
P04114

grupo funcional

ester
phospholipid

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

Informações sobre genes

human ... APOB(338) , APOC2(344) , APOE(348)

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Ações bioquímicas/fisiológicas

High density lipoprotein (HDL) serves as the transit agent for cholesterol away from blood, tissues, and organs of the body to the liver, where cholesterol breakdown occurs. This process ultimately helps to remove cholesterol from the arteries. Colloquially known as the "good cholesterol", HDL makes up 20%-30% of the total cholesterol in the body.

HDL is used in cardiovascular research and the development of potential therapeutic approaches to cardiovascular risk management.

forma física

Solution in 150 mM NaCl and 0.01% EDTA, pH 7.4.

Outras notas

View more information on lipoprotein function and lipid transport at www.sigma-aldrich.com/enzymeexplorer

Exoneração de responsabilidade

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Tisha R Joy
Pharmacology & therapeutics, 135(1), 18-30 (2012-04-03)
Reduction in low-density lipoprotein cholesterol (LDL-C) levels has been associated with a 25-30% reduction in cardiovascular disease risk. However, there still remains a significant and quantifiable risk. Since epidemiologic data have demonstrated that low levels of high-density lipoprotein cholesterol (HDL-C)
Kyung-Hyun Cho
Medicines (Basel, Switzerland), 8(7) (2021-08-07)
The composition and properties of apolipoprotein (apo) A-I and apoA-II in high-density lipoproteins (HDL) might be critical to SARS-CoV-2 infection via SR-BI and antiviral activity against COVID-19. HDL containing native apoA-I showed potent antiviral activity, while HDL containing glycated apoA-I
Mark J Cziraky et al.
Journal of managed care pharmacy : JMCP, 14(8 Suppl), S3-28 (2009-11-07)
Most clinicians recognize the importance of reducing low-density lipoprotein cholesterol (LDL-C) and, therefore, address this therapeutic need to decrease cardiovascular disease risk. In addition to the critical role that LDL-C plays, recent studies have shown the contribution of other lipid
Santiago Redondo et al.
Lipids in health and disease, 10, 175-175 (2011-10-12)
Epidemiologic studies indicate a strong inverse correlation between plasma levels of high-density lipoproteins (HDL) and cardiovascular disease (CVD). The most relevant cardioprotective mechanism mediated by HDL is thought to be reverse cholesterol transport (RCT). New insights in HDL biology and
Menno Hoekstra et al.
Current opinion in lipidology, 23(2), 127-132 (2012-01-21)
Scavenger receptor class B type I (BI) is primarily known for its role in the selective uptake of cholesteryl esters from HDL, the final step in reverse cholesterol transport. Here, we will discuss findings that highlight the recently established novel
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