A4327
Albumina
lyophilized powder, essentially protease free, ≥96% (agarose gel electrophoresis)
Sinônimo(s):
HSA
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About This Item
Produtos recomendados
fonte biológica
human
Nível de qualidade
Ensaio
≥96% (agarose gel electrophoresis)
Formulário
lyophilized powder
peso molecular
monomer calculated mol wt 66478 Da
técnica(s)
tissue culture: suitable
Impurezas
HIV I and HIVII, HCV and HBsAg, tested negative
solubilidade
H2O: soluble 50 mg/mL
nº de adesão UniProt
atividade externa
Alkaline phosphatase ≤0.001 units/mg protein
Peroxidase ≤0.001 units/mg protein
Protease ≤0.0001 units/mg protein
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
FC(F)(F)C(F)(F)C(F)(F)F
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
chave InChI
QYSGYZVSCZSLHT-UHFFFAOYSA-N
Informações sobre genes
human ... ALB(213)
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Descrição geral
Albumin is the most copious protein in blood plasma. Produced in the liver, serum albumin serves as a carrier protein for biomolecules like as fatty acids, amino acids, and steroids.
This human serum albumin (HSA) product has been specially tested and evaluated to be low in the following properties:
Serum albumin is used in various applications related to molecular biology, notably as an inert protein stabilizer for stock solutions of enzymes and proteins of interest. In such applications, it is thus important for the HSA to be protease free, to maintain the integrity of the protein or enzyme of interest.
Protease-free HSA is especially useful for applications like:
(b) Nucleic acid hybridization
(c) Radioimmunoassay (RIA)
This human serum albumin (HSA) product has been specially tested and evaluated to be low in the following properties:
- Essentially protease-free / low protease content
- Low alkaline phosphatase content
- Low peroxidase content
Serum albumin is used in various applications related to molecular biology, notably as an inert protein stabilizer for stock solutions of enzymes and proteins of interest. In such applications, it is thus important for the HSA to be protease free, to maintain the integrity of the protein or enzyme of interest.
Protease-free HSA is especially useful for applications like:
- Enzyme assays
- Protein-based assays
- Protease-sensitive techniques such as:
(b) Nucleic acid hybridization
(c) Radioimmunoassay (RIA)
Aplicação
Albumin was used to test its effect on the in vitro bactericidal activity of cefditoren against penicillin-resistant Streptococcus pneumonia. It has been clinically used in serious and often life-threatening conditions, such as shock and blood loss due to trauma, burns, and surgery.
It was used to test the effect of non-enzymatic glycation on the unfolding of human serum albumin. It was also used to test the two distinct pathways used by intestinal epithelial cells for HLA class II antigen processing.
It was used to test the effect of non-enzymatic glycation on the unfolding of human serum albumin. It was also used to test the two distinct pathways used by intestinal epithelial cells for HLA class II antigen processing.
Ações bioquímicas/fisiológicas
A albumina sérica funciona como proteína carreadora para esteroides, ácidos graxos e hormônios tiroidianos, além de ser vital na regulação das pressões osmóticas coloidais do sangue. Observa-se também que a albumina se liga a substâncias exógenas, especialmente medicamentos (p. ex., ibuprofeno, varfarina) e influencia fortemente a sua farmacocinética. O estresse oxidativo que leva a alterações no estado redox da albumina tem efeitos amplamente variados sobre a sua função fisiológica.
As albuminas são proteínas monoméricas solúveis encontradas nos fluidos e tecidos corporais de animais e em algumas sementes de plantas. A albumina sérica funciona como proteína carreadora para esteroides, ácidos graxos e hormônios tiroidianos. As albuminas séricas também são vitais na regulação das pressões osmóticas coloidais do sangue.
Características e benefícios
- Low protease activity / essentially protease-free (≤ 0.0001 units/mg protein)
- Low alkaline phosphatase activity (≤ 0.001 units/mg protein)
- Low peroxidase activity (≤ 0.001 units/mg protein)
Nota de preparo
Prepared from A1653
Outras notas
Vide mais informações em albumina sérica humana.
Exoneração de responsabilidade
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
produto relacionado
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves
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Archives of biochemistry and biophysics, 444(2), 92-99 (2005-11-29)
We monitored the unfolding of human serum albumin (HSA) and glycated human serum albumin (gHSA) subjected to guanidine hydrochloride (GndHCl) by using fluorescence and circular dichroism (CD) spectroscopy. A two-state model with sloping baselines best described the Trp-214 fluorescence unfolding
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The Journal of antimicrobial chemotherapy, 60(1), 156-158 (2007-05-08)
Attempts to interpret antibiotic pharmacodynamics using reported protein binding may underestimate true activity. To elucidate this issue we examined bacterial killing kinetics at cefditoren concentrations equal to C(max) in the presence of 90% human serum or albumin at physiological concentrations.
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