A4142

Azaserine

≥98% (TLC)

• Sinônimo(s): O-Diazoacetyl-L-serine
• Fórmula empírica (Notação de Hill): C₅H₇N₃O₄
• Número CAS: 115-02-6
• Peso molecular: 173.13
• Beilstein: 1726602
• Número CE: 204-061-6
• Número MDL: MFCD00036802
• Código UNSPSC: 12352209
• ID de substância PubChem: 24890830
• NACRES: NA.26

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (TLC)
• Formulário: powder
• cor: off-white to yellow-green
• espectro de atividade do antibiótico: fungi
• Modo de ação: enzyme | inhibits
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: N[C@@H](COC(=O)C=[N+]=[N-])C(O)=O
• InChI: 1S/C5H7N3O4/c6-3(5(10)11)2-12-4(9)1-8-7/h1,3H,2,6H2,(H,10,11)/t3-/m0/s1
• chave InChI: MZZGOOYMKKIOOX-VKHMYHEASA-N

Descrição

Descrição geral

Chemical structure: amino acid derivatives

Aplicação

Used in cell culture for the selection of HGPRT revertants.

Ações bioquímicas/fisiológicas

Azaserine is an antibiotic and antifungal; it may also act as a tumor inducer. It is a structural analog of glutamine and competes with glutamine in binding to enzymes involved in purine biosynthesis. Azaserine inhibits purine biosynthesis by covalently reacting with cysteine residues in the enzyme active sites, such as in formylglycinamide ribonucleotide amidotransferase and PRPP amidotransferase. Azaserine can induce DNA damage via the formation of carboxymethylated bases and O⁶-methylguanine. Secretion of exo-1,3-β-glucanase and germ-tube formation of Candida albicans were inhibited by azaserine.

Informações de segurança

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H301,H351
• Declarações de precaução: P201 - P301 + P310 + P330
• Classificações de perigo: Acute Tox. 3 Oral - Carc. 2
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges