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347795

Sigma-Aldrich

Sodium dichloroacetate

98%

Sinônimo(s):

Dichloroacetic acid sodium salt

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About This Item

Fórmula linear:
Cl2CHCO2Na
Número CAS:
2156-56-1
Peso molecular:
150.92
Número CE:
218-461-3
Número MDL:
MFCD00070489
Código UNSPSC:
12352302
ID de substância PubChem:
24861527
NACRES:
NA.22

Ensaio

98%

Impurezas

<2% ethyl alcohol

pf

198 °C (dec.) (lit.)

cadeia de caracteres SMILES

[Na+].[O-]C(=O)C(Cl)Cl

InChI

1S/C2H2Cl2O2.Na/c3-1(4)2(5)6;/h1H,(H,5,6);/q;+1/p-1

chave InChI

LUPNKHXLFSSUGS-UHFFFAOYSA-M

Informações sobre genes

human ... PDK1(5163) , PDK2(5164) , PDK3(5165) , PDK4(5166)

Descrição geral

Sodium dichloroacetate is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that exhibits potent anti-leukemic activity.

Aplicação

Sodium dichloroacetate can be used as an organic salt precursor for synthesizing microporous carbon that is useful in developing carbon-based adsorbents.

Outras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335,H351

Classificações de perigo

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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Sodium chloroacetate 98%

Sigma-Aldrich

291773

Sodium chloroacetate

6-Aminonicotinamide 99%

Sigma-Aldrich

A68203

6-Aminonicotinamide

Hexokinase II Inhibitor II, 3-BP The Hexokinase II Inhibitor II, 3-BP, also referenced under CAS 1113-59-3, controls the biological activity of Hexokinase II. This small molecule/inhibitor is primarily used for Cell Structure applications.

Millipore

376817-M

Hexokinase II Inhibitor II, 3-BP

Methyl dichloroacetate &#8805;99%

Sigma-Aldrich

35840

Methyl dichloroacetate

Preparing microporous carbon from solid organic salt precursors using in situ templating and a fixed-bed reactor.
Atkinson JD & Rood MJ.
Microporous and Mesoporous Materials : The Official Journal of the International Zeolite Association, 160, 174-181 (2012)
Marie-Aline Neveu et al.
Oncotarget, 7(49), 81741-81749 (2017-01-14)
Reverting glycolytic metabolism is an attractive strategy for cancer therapy as upregulated glycolysis is a hallmark in various cancers. Dichloroacetate (DCA), long used to treat lactic acidosis in various pathologies, has emerged as a promising anti-cancer drug. By inhibiting the
Mito-DCA: a mitochondria targeted molecular scaffold for efficacious delivery of metabolic modulator dichloroacetate.
Pathak RK, et al.
ACS Chemical Biology, 9(5), 1178-1187 (2014)
Mario Ammendola et al.
Scientific reports, 10(1), 6521-6521 (2020-04-18)
The growing interest of oncologists in natural compounds such as polyphenols and flavonoids is encouraging the development of innovative and efficient carriers for the delivery of those drugs. This study examines carboxymethyl chitosan-based microcapsules created by spray drying as a
Han Shen et al.
Molecular cancer therapeutics, 14(8), 1794-1804 (2015-06-13)
Because radiotherapy significantly increases median survival in patients with glioblastoma, the modulation of radiation resistance is of significant interest. High glycolytic states of tumor cells are known to correlate strongly with radioresistance; thus, the concept of metabolic targeting needs to
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