50838
(R)-Mevalonic acid lithium salt
≥93.0% (qNMR)
Sinônimo(s):
Lithium (R)-3,5-dihydroxy-3-methylpentanoate, Lithium (R)-3,5-dihydroxy-3-methylvalerate, R-MVA-Li
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About This Item
Fórmula empírica (Notação de Hill):
C6H11LiO4
Número CAS:
Peso molecular:
154.09
Número MDL:
Código UNSPSC:
12352106
ID de substância PubChem:
NACRES:
NA.25
Ensaio:
≥93.0% (qNMR)
Produtos recomendados
Ensaio
≥93.0% (qNMR)
atividade óptica
[α]/D -26±3°, c = 0.1 in 0.1 M HCl (16 h)
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
[Li+].C[C@@](O)(CCO)CC([O-])=O
InChI
1S/C6H12O4.Li/c1-6(10,2-3-7)4-5(8)9;/h7,10H,2-4H2,1H3,(H,8,9);/q;+1/p-1/t6-;/m1./s1
chave InChI
PVWNXFFXFNEHDZ-FYZOBXCZSA-M
Aplicação
Mevalonic acid may be used as a reference material in assays for the separation or detection of mevalonic acid. Mevalonic acid is a precursor of isopentenyl pyrophosphate (IPP) and the mevalonate pathway which leads to isoprenoid biosynthesis. Mevalonic acid may be used as a substrate to identify and characterize mevalonate kinase(s).
Ações bioquímicas/fisiológicas
Mevalonic acid, is an intermediate in the mevalonate pathway, producing terpenes and steroids. This function provides treatment options metabolic disorders , R-mevalonate accumulates in patients with the autosomal recessively inherited mevalonic acidurias, an inborn error of cholesterol and nonsterol isoprene biosynthesis.
Embalagem
Bottomless glass bottle. Contents are inside inserted fused cone.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 4 Oral - Eye Irrit. 2
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Discovery and chemistry of mevalonic acid.
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Advances in Enzymology and Related Areas of Molecular Biology, 23, 471-483 (1961)
S M Houten et al.
Cellular and molecular life sciences : CMLS, 60(6), 1118-1134 (2003-07-16)
Mevalonate kinase (MK) is an essential enzyme in the isoprenoid biosynthesis pathway which produces numerous biomolecules (isoprenoids) involved in a variety of cellular processes. The indispensability of MK and isoprenoid biosynthesis for human health is demonstrated by the identification of
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Mevalonic aciduria (MVA) and hyperimmunoglobulinemia D syndrome (HIDS) represent the two ends of a clinical spectrum of disease caused by deficiency of mevalonate kinase (MVK), the first committed enzyme of cholesterol biosynthesis. At least 30 patients with MVA and 180
G Hoffmann et al.
The New England journal of medicine, 314(25), 1610-1614 (1986-06-19)
A two-year-old boy presented with severe failure to thrive, developmental delay, anemia, hepatosplenomegaly, central cataracts, and dysmorphic features. Quantitative analyses of urinary organic acids revealed massive excretion of mevalonic acid, a metabolic precursor of cholesterol and nonsterol isoprenes: 46,000 to
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