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26978

Sigma-Aldrich

Cloreto de colina

BioUltra, ≥99.0% (AT)

Sinônimo(s):

Cloreto de (2-hidroxietil)trimetilamônio

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About This Item

Fórmula linear:
(CH3)3N(Cl)CH2CH2OH
Número CAS:
67-48-1
Peso molecular:
139.62
Beilstein:
3563126
Número CE:
200-655-4
Número MDL:
MFCD00011721
Código UNSPSC:
12352211
ID de substância PubChem:
57648187
NACRES:
NA.25

fonte biológica

synthetic

Nível de qualidade

200

linha de produto

BioUltra

Ensaio

≥99.0% (AT)

forma

powder or crystals

Impurezas

insoluble matter, passes filter test

cor

colorless to white

pH

5.0-7.5 (25 °C, 1 M in H2O)

pf

302-305 °C (dec.) (lit.)

solubilidade

H2O: 1 M, clear, colorless

traços de ânion

sulfate (SO42-): ≤50 mg/kg

traços de cátion

Al: ≤5 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

1 M in H2O

Absorção UV

λ: 260 nm Amax: 0.015
λ: 280 nm Amax: 0.010

cadeia de caracteres SMILES

[Cl-].C[N+](C)(C)CCO

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

chave InChI

SGMZJAMFUVOLNK-UHFFFAOYSA-M

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Ações bioquímicas/fisiológicas

Choline is an essential nutrient, commonly grouped with the B complex vitamins, that plays key roles in many biological processes.

Substratos

Substrato de colina acetiltransferase

Outras notas

Restores cholinergic, biochemical and pharmacological activities in striata of decorticated rats
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Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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S Consolo et al.
Journal of neurochemistry, 54(2), 571-577 (1990-02-01)
Interruption of the corticostriatal pathway by undercutting the frontal cortex resulted after 2 weeks in a 40% reduction of basal acetylcholine (ACh) release in vivo, and in inhibition of the striatal sodium-dependent high-affinity uptake of choline (SDHACU) to the same
Sotirios Chondrogiannis et al.
European journal of nuclear medicine and molecular imaging, 40(9), 1356-1364 (2013-05-15)
The aims of the study were (a) to evaluate the diagnostic role, by means of positive detection rate (PDR), of ¹⁸F-choline (CH) positron emission tomography (PET)/CT in patients with prostate cancer treated with radiotherapy, with curative intent, and suspicion of
Mohsen Beheshti et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(6), 833-840 (2013-04-06)
We evaluated the potential of (18)F-fluoromethyldimethyl-2-hydroxyethyl-ammonium (FCH) PET/CT in the detection of recurrent disease or distant metastases and correlated its diagnostic accuracy with prostate-specific antigen (PSA) levels in prostate cancer patients with biochemical evidence of recurrence. Furthermore, the influences of
Elisabeth Traiffort et al.
Molecular aspects of medicine, 34(2-3), 646-654 (2013-03-20)
The Na(+)-independent, high affinity choline carrier system proposed to supply choline for the synthesis of cell membrane phospholipids was recently associated with SLC44 family members (SLC44A1-5) also called choline-like transporter family. SLC44A1 is widely expressed throughout the nervous system in
Zhuo Li et al.
Biochimica et biophysica acta, 1840(7), 2112-2122 (2014-03-19)
Choline kinase has three isoforms encoded by the genes Chka and Chkb. Inactivation of Chka in mice results in embryonic lethality, whereas Chkb(-/-) mice display neonatal forelimb bone deformations. To understand the mechanisms underlying the bone deformations, we compared the
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