17929

O-Methyl-O′-succinylpolyethylene glycol 5′000

• Sinônimo(s): Polyethylene glycol, O-(Succinyl)-O′-methylpolyethylene glycol 5′000, Polyethylene glycol 5000 monomethyl ether succinate
• Fórmula linear: CH₃O(CH₂CH₂O)_nCOCH₂CH₂COOH
• Número CAS: 31961-02-1
• Número MDL: MFCD00284260
• Código UNSPSC: 51171641
• NACRES: NA.26

Propriedades

• forma: powder
• peso molecular: M_r ~5100
• pf: 56-60 °C
• Ω-final: carboxylic acid
• α-final: methoxy
• temperatura de armazenamento: −20°C

Descrição

Aplicação

Polyethylene glycol 5000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.

Soluble polymer for solid phase synthesis of imines and β-lactams; attaching peptides to PEG

Ações bioquímicas/fisiológicas

O-Methyl-O′-succinylpolyethylene glycol 5′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves