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Documentos Principais

202487

Sigma-Aldrich

Poly(ethylene glycol) methyl ether

average MN 550, methoxy, hydroxyl

Sinônimo(s):

Polyethylene glycol, Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, mPEG

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About This Item

Fórmula linear:
CH3(OCH2CH2)nOH
Número CAS:
Número MDL:
Código UNSPSC:
12162002
ID de substância PubChem:
NACRES:
NA.23

Nome do produto

Poly(ethylene glycol) methyl ether, average Mn 550

densidade de vapor

>1 (vs air)

pressão de vapor

0.05 mmHg ( 20 °C)

Formulário

semisolid

peso molecular

average Mn 550

índice de refração

n20/D 1.455

viscosidade

7.5 cSt(210 °F)(lit.)

temperatura de transição

Tm 20 °C

densidade

1.089 g/mL at 25 °C

Ω-final

hydroxyl

α-final

methoxy

cadeia de caracteres SMILES

O(CCO)C

InChI

1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3

chave InChI

XNWFRZJHXBZDAG-UHFFFAOYSA-N

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Aplicação

Poly(ethylene glycol) methyl ether can be used as a pore-forming agent to prepare polysulfone membranes with enhanced hydrophilicity.

Poly(ethylene glycol) methyl ether-grafted polyamidoamine (PAMAM) dendrimers can be used as drug carrier systems for anticancer drugs.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

359.6 °F - closed cup

Ponto de fulgor (°C)

182 °C - closed cup


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Smita K Pawar et al.
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Efficacy of anticancer drug is limited by the severe adverse effects induced by drug; therefore the crux is in designing delivery systems targeted only to cancer cells. Toward this objectives, we propose, synthesis of poly(ethylene glycol) (PEG)-doxorubicin (DOX) prodrug conjugates
Mark G P Saifer et al.
Molecular immunology, 57(2), 236-246 (2013-11-10)
The use of methoxypoly(ethylene glycol) (mPEG) in PEG conjugates of proteins and non-protein therapeutic agents has led to the recognition that the polymer components of such conjugates can induce anti-PEG antibodies (anti-PEGs) that may accelerate the clearance and reduce the
Jiani Zheng et al.
Langmuir : the ACS journal of surfaces and colloids, 28(37), 13261-13273 (2012-08-28)
Alginate/chitosan/alginate (ACA) hydrogel microcapsules were modified with methoxy poly(ethylene glycol) (MPEG) to improve protein repellency and biocompatibility. Increased MPEG surface graft density (n(S)) on hydrogel microcapsules was achieved by controlling the grafting parameters including the buffer layer substrate, membrane thickness
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Artigos

Fouling Resistant Biomimetic Poly(Ethylene Glycol) Based Grafted Polymer Coatings

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

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