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Merck
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Key Documents

19-4060

Sigma-Aldrich

NMP

SAJ first grade, ≥98.0%

Sinônimo(s):

1-Metil-2-pirrolidona, N-metil-2-pirrolidona, Polimerização mediada por nitróxidos

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About This Item

Fórmula empírica (Notação de Hill):
C5H9NO
Número CAS:
Peso molecular:
99.13
Beilstein:
106420
Número CE:
Número MDL:
Código UNSPSC:
12352005
ID de substância PubChem:

product name

1-metil-2-pirrolidinona, SAJ first grade, ≥98.0%

grau

SAJ first grade

densidade de vapor

3.4 (vs air)

pressão de vapor

0.29 mmHg ( 20 °C)
0.99 mmHg ( 40 °C)

Ensaio

≥98.0%

forma

liquid

temperatura de autoignição

518 °F

Lim. expl.

9.5 %

disponibilidade

available only in Japan

índice de refração

n20/D 1.47 (lit.)

pH

7.7-8

pb

202 °C (lit.)
81-82 °C/10 mmHg (lit.)

pf

−24 °C (lit.)

densidade

1.028 g/mL at 25 °C (lit.)

cadeia de caracteres SMILES

CN1CCCC1=O

InChI

1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3

chave InChI

SECXISVLQFMRJM-UHFFFAOYSA-N

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Pictogramas

Health hazardExclamation mark

Palavra indicadora

Danger

Frases de perigo

Classificações de perigo

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

195.8 °F - Pensky-Martens closed cup

Ponto de fulgor (°C)

91 °C - Pensky-Martens closed cup

Equipamento de proteção individual

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


Certificados de análise (COA)

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B A Jönsson et al.
Journal of chromatography. B, Biomedical sciences and applications, 694(2), 351-357 (1997-07-04)
A method for simultaneous determination of 5-hydroxy-N-methylpyrrolidone and 2-hydroxy-N-methylsuccinimide in urine is described. These compounds are metabolites of N-methyl-2-pyrrolidone, a powerful and widely used organic solvent. 5-Hydroxy-N-methylpyrrolidone and 2-hydroxy-N-methylsuccinimide were purified from urine by adsorption to a C8 solid-phase extraction
Laura Vogelaar et al.
Small (Weinheim an der Bergstrasse, Germany), 1(6), 645-655 (2006-12-29)
Phase separation micromolding (PSmicroM) is a versatile microfabrication technique that can be used to structure a very broad range of polymers, including block copolymers and biodegradable and conductive polymers without the need for clean-room facilities. By incorporating a subsequent process
Nurit Atar et al.
ACS applied materials & interfaces, 7(22), 12047-12056 (2015-05-07)
In low Earth orbit (LEO), hazards such as atomic oxygen (AO) or electrostatic discharge (ESD) degrade polymeric materials, specifically, the extensively used polyimide (PI) Kapton. We prepared PI-based nanocomposite films that show both AO durability and ESD protection by incorporating
Hsiao-Chun Wang et al.
European journal of medicinal chemistry, 84, 312-334 (2014-07-19)
Bioisosteric replacement of acylureido moiety in 6-acylureido-3-pyrrolylmethylidene-2-oxoindoline derivatives resulted in a series of malonamido derivatives with indolin-2-one scaffold (11-14). Further conformational restrictions of the malonamido moiety led to 2-oxo-1,2-dihydropyridine (21-25) or a 4-oxo-1,4-dihydropyridine derivatives (31-36). 4-Oxo-1,4-dihydropyridine derivatives were more potent
Ajit Dhananjay Jagtap et al.
European journal of medicinal chemistry, 85, 268-288 (2014-08-05)
A series of 6-acylureido derivatives containing a 3-(pyrrol-2-ylmethylidene)indolin-2-one scaffold were synthesized as potential dual Aurora B/FLT3 inhibitors by replacing the 6-arylureido moiety in 6-arylureidoindolin-2-one-based multi-kinase inhibitors. (Z)-N-(2-(pyrrolidin-1-yl)ethyl)-5-((6-(3-(2-fluoro-4-methoxybenzoyl)ureido)-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (54) was identified as a dual Aurora B/FLT3 inhibitor (IC50 = 0.4 nM and 0.5 nM, respectively).

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