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Merck
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Key Documents

MAB5492

Sigma-Aldrich

Anti-Huntingtin Antibody, a.a. 1-82

ascites fluid, clone 2B4, Chemicon®

Sinônimo(s):

Anti-Huntingtin, Anti-Huntingtin Antibody, Detection Antibody

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

forma do anticorpo

ascites fluid

tipo de produto de anticorpo

primary antibodies

clone

2B4, monoclonal

reatividade de espécies

human

fabricante/nome comercial

Chemicon®

técnica(s)

ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

Isotipo

IgG1

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

dry ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

Especificidade

Reacts huntingtin protein, amino acids 1-82. The antibody recognizes wild type and mutant huntingtin.

Imunogênio

Epitope: a.a. 1-82
Recombinant human huntingtin, amino acids 1-82.

Aplicação

Anti-Huntingtin Antibody, a.a. 1-82 is an antibody against Huntingtin for use in ELISA, IC, IH & WB.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Western blot: 1:500-1:5,000

Immunocytochemistry (1): 1:500-1:5,000

Immunohistochemistry (1,2): 1:500-1:5,000

ELISA: 1:500-1:5,000

Optimal working dilutions must be determined by end user.

Descrição-alvo

348 kDa

forma física

Ascites fluid containing no preservatives.
Unpurified

Armazenamento e estabilidade

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Nota de análise

Control
Normal human cerebral cortex lysate, Mouse brain cortex samples from HD or wild type mice

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Visite a Biblioteca de Documentos

Acetylation targets mutant huntingtin to autophagosomes for degradation.
Hyunkyung Jeong,Florian Then,Thomas J Melia,Joseph R Mazzulli,Libin Cui,Jeffrey N Savas et al.
Cell null
Jonathan H Fox et al.
The Journal of biological chemistry, 286(20), 18320-18330 (2011-04-02)
Huntington disease (HD) is a progressive neurodegenerative disorder caused by expression of polyglutamine-expanded mutant huntingtin protein (mhtt). Most evidence indicates that soluble mhtt species, rather than insoluble aggregates, are the important mediators of HD pathogenesis. However, the differential roles of
Xiaofeng Gu et al.
Neuron, 85(4), 726-741 (2015-02-11)
The nucleus is a critical subcellular compartment for the pathogenesis of polyglutamine disorders, including Huntington's disease (HD). Recent studies suggest the first 17-amino-acid domain (N17) of mutant huntingtin (mHTT) mediates its nuclear exclusion in cultured cells. Here, we test whether
Inducing huntingtin inclusion formation in primary neuronal cell culture and in vivo by high-capacity adenoviral vectors expressing truncated and full-length huntingtin with polyglutamine expansion.
Bin Huang, Johannes Schiefer, Christian Sass, Christoph M Kosinski, Stefan Kochanek
The journal of gene medicine null
The composition of the polyglutamine-containing proteins influences their co-aggregation properties.
Bak D, Milewski M
Cell Biology International null

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