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Documentos Principais

MAB1914P

Sigma-Aldrich

Anti-Laminin gamma 1 Antibody, clone A5

clone A5, Chemicon®, from rat

Sinônimo(s):

LAMC1

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

rat

Nível de qualidade

100

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

A5, monoclonal

reatividade de espécies

mouse, human

fabricante/nome comercial

Chemicon®

técnica(s)

immunohistochemistry: suitable (paraffin)

Isotipo

IgG2aκ

nº de adesão UniProt

P11047

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... LAMC1(3915)

Descrição geral

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Variations in the expression of laminins have been observed in embryogenesis, organogenesis, post traumatic healing and cancer. Laminins have been provoked by the discovery of their ability to promote neurite regeneration. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively). The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly.

Imunogênio

Basement membrane protein preparation from mouse EHS tumor.

Aplicação

Detect Laminin gamma 1 using this Anti-Laminin gamma 1 Antibody, clone A5 validated for use in IH(P).
Research Sub Category
ECM Proteins

Adhesion (CAMs)

Descrição-alvo

177 kDa

forma física

Format: Purified
Purified rat immunoglobulin in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.

Nota de análise

Control
Tubular carcinoma of the colon and fibroneuroma

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Fenny Wiradjaja et al.
Disease models & mechanisms, 6(6), 1426-1433 (2013-09-21)
Fras1-related extracellular matrix protein 1 (FREM1) is required for epidermal adhesion during embryogenesis, and mice lacking the gene develop fetal skin blisters and a range of other developmental defects. Mutations in members of the FRAS/FREM gene family cause diseases of
Daniel Öhlund et al.
BMC cancer, 13, 154-154 (2013-03-28)
Pancreatic cancer shows a highly aggressive and infiltrative growth pattern and is characterized by an abundant tumor stroma known to interact with the cancer cells, and to influence tumor growth and drug resistance. Cancer cells actively take part in the
Alejandro E Mayorca-Guiliani et al.
Nature protocols, 14(12), 3395-3425 (2019-11-11)
The extracellular matrix (ECM) is a major regulator of homeostasis and disease, yet the 3D structure of the ECM remains poorly understood because of limitations in ECM visualization. We recently developed an ECM-specialized method termed in situ decellularization of tissues

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