580555

Paclitaxel

from Taxus sp., ≥97% (HPLC), solid, DNA synthesis inhibitor, Calbiochem^®

• Sinônimo(s): Paclitaxel, Taxus sp., Baccatin III N-benzyl-β-phenylisoserine Ester, TAXOL^®
• Fórmula empírica (Notação de Hill): C₄₇H₅₁NO₁₄
• Número CAS: 33069-62-4
• Peso molecular: 853.91
• Número MDL: MFCD00869953
• Código UNSPSC: 41116107
• NACRES: NA.77

Propriedades

• Nome do produto: Paclitaxel, Taxus sp., Antitumor and antileukemic agent isolated from the bark of the yew tree.
• Nível de qualidade: 100
• descrição: Merck USA index - 14, 6982
• Ensaio: ≥98% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated; protect from light
• cor: white
• solubilidade: methanol: 1 mg/mL; DMSO: 10 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: N([C@H]([C@@H](O)C(=O)O[C@H]3C[C@]4([C@H](C6[C@]7([C@H](OC7)C[C@@H]([C@]6(C(=O)[C@@H](C(=C3C)C4(C)C)OC(=O)C)C)O)OC(=O)C)OC(=O)c5ccccc5)O)c2ccccc2)C(=O)c1ccccc1
• InChI: 1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38?,40-,45+,46-,47+/m0/s1
• chave InChI: RCINICONZNJXQF-VAZQATRQSA-N

Descrição

Descrição geral

Antitumor and anti-leukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G₂/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.

Antitumor and antileukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G₂/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
Promotes assembly of microtubules and inhibits tubulins disassembly

Product does not compete with ATP.

Reversible: no

Advertência

Toxicity: Carcinogenic / Teratogenic (D)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Outras notas

Derry, W.B., et al. 1995. Biochemistry 34, 2203.
Milas, L., et al. 1995. Cancer Chemother. Pharmacol.35, 297.
Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
Hornback, N.B., et al. 1994. In Vivo8, 819.
Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
Ding, A.H., et al. 1990. Science248, 370.
Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci.97, 101.
Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Taxol is a registered trademark of Bristol-Myers Squibb Co.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H341,H360FD,H372
• Declarações de precaução: P202 - P260 - P264 - P280 - P308 + P313 - P405
• Classificações de perigo: Muta. 2 - Repr. 1B - STOT RE 1
• Órgãos-alvo: Central nervous system,Bone marrow,Cardio-vascular system
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable