399275

N^ω-Hydroxy-nor-L-arginine, Diacetate Salt

A potent, selective, competitive, and high affinity inhibitor of arginase.

• Sinônimo(s): N^ω-Hydroxy-nor-L-arginine, Diacetate Salt, nor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H
• Fórmula empírica (Notação de Hill): C₅H₁₂N₄O₃ · 2C₂H₄O₂
• Número CAS: 189302-40-7
• Peso molecular: 296.28
• Número MDL: MFCD01318777
• Código UNSPSC: 12352209
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥97% (TLC)
• Formulário: solid
• potência: 2 μM IC₅₀
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic)
• cor: off-white
• solubilidade: water: 50 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: N(O)\C(=N\CC[C@H](N)C(=O)O)\N.OC(=O)C.OC(=O)C
• chave InChI: PQFYTZJPYBMTCT-QTNFYWBSSA-N

Descrição

Descrição geral

A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC₅₀ = 2 µM) and mouse macrophages (IC₅₀ = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.

Ações bioquímicas/fisiológicas

Primary Target
arginase from rat liver

Secondary Target
mouse macrophages (IC₅₀ = 50 µM)

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Outras notas

Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
Moali, C., et al. 2000. Biochemistry 39, 8208.
Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
Moali, C., et al. 1998. Biochemistry 37, 10453.
Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable