3541

Glutathione, Reduced, Free Acid

>98% (titration), solid, endogenous antioxidant, Calbiochem^®

• Sinônimo(s): Glutathione, Reduced, Free Acid, γ-Glu-Cys-Gly, GSH
• Fórmula empírica (Notação de Hill): C₁₀H₁₇N₃O₆S
• Número CAS: 70-18-8
• Peso molecular: 307.32
• Número MDL: MFCD00065939
• Código UNSPSC: 12352209
• NACRES: NA.25

Propriedades

• Nome do produto: Glutathione, Reduced, Free Acid, Glutathione, Reduced, Free Acid, CAS 70-18-8, is a tripeptide that serves as an endogenous antioxidant and provides protection against auto-oxidation.
• Nível de qualidade: 200
• descrição: RTECS - MC0556000; Merck USA index - 14, 4475
• Ensaio: >98% (titration)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic)
• cor: white
• solubilidade: water: 1 mg/mL; DMF: 10 mg/mL; ethanol: 5 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: SCC(NC(=O)CCC([N+H3])C(=O)[O-])C(=O)NCC(=O)O
• InChI: 1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)
• chave InChI: RWSXRVCMGQZWBV-UHFFFAOYSA-N

Descrição

Descrição geral

Glutathione is a tripeptide composed of cysteine, glycine, and glutamic acid. In cells glutathione either exists as reduced (GSH) and oxidized (GSSG). The ratio of glutathione reduced (GSH) to glutathione oxidized (GSSG) determines the cell’s redox status. Healthy resting cells have a GSH/GSSG ratio >100. In cells under oxidative stress, the GSH/GSSG ratio drops to between 1 and 10. Glutathione has also been identified as the thiol buffer that keeps sulfohydryl groups in the reduced form of many proteins. It is produced solely in the cytochrome P450 system and actively pumped to mitochondria. GSH depletion can lead to Neurodegenerative disorders, Pulmonary disease, Immune diseases, Cardiovascular diseases, Chronic age-related diseases, Liver disease, Cystic fibrosis and Aging process itself.

Aplicação

Glutathione, Reduced, Free Acid has been used to elute the GST-OTUD6A proteins after purification using Glutathione Sepharose.

Ações bioquímicas/fisiológicas

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable