203291

Bisindolylmaleimide I, Hydrochloride

An enhanced water-soluble form of Bisindolylmaleimide I.

• Sinônimo(s): Bisindolylmaleimide I, Hydrochloride, 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl
• Fórmula empírica (Notação de Hill): C₂₅H₂₄N₄O₂ · xHCl
• Número CAS: 176504-36-2
• Peso molecular: 412.48 (free base basis)
• Número MDL: MFCD00236429
• Código UNSPSC: 12352111
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze
• cor: orange-red
• solubilidade: water: 10 mg/mL; DMSO: 20 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cl.N1C(=O)C(=C(C1=O)c4c5c([nH]c4)cccc5)c2c3c([n](c2)CCCN(C)C)cccc3
• InChI: 1S/C25H24N4O2.ClH/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20;/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31);1H
• chave InChI: XRAMWNCMYJHGGH-UHFFFAOYSA-N

Descrição

Descrição geral

A reversible and ATP-competitive inhibitor of protein kinase C (K_i = 10 nM). Inhibits protein kinase A at much higher concentrations (K_i = 2 µM). An enhanced water soluble form of Bisindolylmaleimide I (Cat. No. 203290).

An enhanced water-soluble form of Bisindolylmaleimide I (Cat. No. 203290). A reversible and ATP-competitive inhibitor of protein kinase C (K_i = 10 nM). May inhibit protein kinase A at much higher concentrations (K_i = 2 µM).

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
Protein kinase C

Product competes with ATP.

Reversible: yes

Target K_i: 10 nM against protein kinase C

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Outras notas

Le Panse, R., et al. 1994. Mol. Pharmacol.46, 445.
Kuchera, S., et al. 1993. Agents Actions 39, C169.
Wilkinson, S.E., et al. 1993. Biochem. J.294, 335.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable