12-338
Wortmannin, (PI3 Kinase inhibitor)
The Wortmannin, (PI3 Kinase inhibitor) controls the biological activity of PI3 Kinase. This small molecule/inhibitor is primarily used for Biochemicals applications.
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About This Item
Código UNSPSC:
12352200
eCl@ss:
32160405
NACRES:
NA.41
Produtos recomendados
Nível de qualidade
Ensaio
≥95% (HPLC)
fabricante/nome comercial
Upstate®
técnica(s)
activity assay: suitable (kinase)
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
Descrição geral
Wortmannin, a fungal metabolite, is a cell-permeable, irreversible inhibitor of phosphatidylinositol 3 kinase (PI3 Kinase) with an IC50 of 5nM. It blocks the catalytic activity of PI3-Kinase without affecting upstream signaling events such as insulin receptor tyrosine kinase activity. Wortmannin also inhibits the activities of myosin light chain kinase and PI4-Kinase at concentrations a hundred times higher than those required to inhibit PI3-Kinase.
Ações bioquímicas/fisiológicas
Inhibitor Type: Kinase
Protein Target: PI3Kγ
Target Sub-Family: PI3K/PI4K
Qualidade
Routinely evaluated by kinase assay.
Purity: ≥95% by HPLC.
Molecular Formula: C23H24O8
Molecular Weight: 428.4
Purity: ≥95% by HPLC.
Molecular Formula: C23H24O8
Molecular Weight: 428.4
forma física
1mg of lyophilized powder packaged under inert gas. White to off-white powder.
Armazenamento e estabilidade
Protect from light. Stable for 2 years as supplied at -20°C. Following reconstitution aliquot and store at -20°. The DMSO/ethanol stock solutions are stable for 1-3 months at -20°C.
Informações legais
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Acute Tox. 2 Dermal
Código de classe de armazenamento
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils.
Ferby, I M, et al.
The Journal of Biological Chemistry, 269, 30485-30488 (1994)
Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin
Okada, T, et al
The Journal of Biological Chemistry, 269, 3568-3573 (1994)
Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption.
Nakamura, I, et al.
Febs Letters, 361, 79-84 (1995)
M J Cross et al.
The Journal of biological chemistry, 270(43), 25352-25355 (1995-10-27)
Wortmannin and its structural analogue demethoxyviridin (DMV) have been reported to be specific inhibitors of phosphatidylinositol 3-kinase activity. Here we report that these compounds are not as selective as assumed and demonstrate inhibition of bombesin-stimulated phospholipase A2 activity by both
Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts.
Wymann, M and Arcaro, A
The Biochemical Journal, 298 Pt 3, 517-520 (1994)
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