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857230P

Avanti

C18:1 LPA

1-(9Z-octadecenyl)-2-hydroxy-sn-glycero-3-phosphate (ammonium salt), powder

Sinônimo(s):

1-O-9-(Z)-octadecenyl-sn-glycero-3-phosphate (ammonium salt); PA(18:1(9Z)e/0:0)

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About This Item

Fórmula empírica (Notação de Hill):
C21H46NO6P
Número CAS:
799279-68-8
Peso molecular:
439.57
Código UNSPSC:
51191904
NACRES:
NA.25

Ensaio

>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)

Formulário

powder

embalagem

pkg of 1 × 1 mg (857230P-1mg)

fabricante/nome comercial

Avanti Research™ - A Croda Brand 857230P

tipo de lipídio

cardiolipins
phospholipids

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

O[C@](COP([O-])(O)=O)([H])COCCCCCCCC/C=C\CCCCCCCC.[NH4+]

chave InChI

WEOSAIXAEGBVPQ-WBIWQBECSA-N

Descrição geral

C18:1 LPA is a bioactive lipid. This lysophosphatidic acid (LPA), soluble lipid is obtained from membrane phospholipid. It is present in blood plasma.

Aplicação

C18:1 LPA is suitable to stimulate human embryonic kidney 293 cells (HEK 293) cells in luciferase assay. It is also suitable to use as an additive in Dulbecco′s modified eagle medium (DMEM) for transwell migration assay, wound‐healing assay and cell proliferation assay.

Ações bioquímicas/fisiológicas

Lysophosphatidic acid (LPA) signaling participates in various cellular processes. It is also associated with neurological disorders, inflammation and cancer.

Embalagem

5 mL Clear Glass Sealed Ampule (857230P-1mg)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

No data available

Ponto de fulgor (°C)

No data available

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Certificados de análise (COA)

Lot/Batch Number

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Sigma-Aldrich

SML0971

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16:0 Cyclic LPA 1-palmitoyl-sn-glycero-2,3-cyclic-phosphate (ammonium salt), powder

Avanti

857323P

16:0 Cyclic LPA

Sigma-Aldrich

Sigma-Aldrich

56575

GenElute™-LPA

R D Moreno-Fernández et al.
Neuropharmacology, 164, 107896-107896 (2019-12-08)
The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the LPA-LPA1-receptor pathway may be involved in mediating the negative consequences
Lysophosphatidic acid and its receptor LPA1 mediate carrageenan induced inflammatory pain in mice
Srikanth M, et al.
European Journal of Pharmacology, 841, 49- 56 (2018)
Autotaxin is a novel target of micro RNA-101-3p
Wang Y, et al.
FEBS Open Bio, 9(4), 707-716 (2019)
Jesica R Williams et al.
The Journal of biological chemistry, 284(25), 17304-17319 (2009-04-16)
Lysophosphatidic acid (LPA) is a ligand for LPA(1-3) of the endothelial differentiation gene family G-protein-coupled receptors, and LPA(4-8) is related to the purinergic family G-protein-coupled receptor. Because the structure-activity relationship (SAR) of GPR92/LPA(5) is limited and whether LPA is its

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