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Key Documents

W224502

Sigma-Aldrich

Carvacrol

≥98%, FCC, FG

Sinônimo(s):

5-Isopropyl-2-methylphenol

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About This Item

Fórmula linear:
(CH3)2CHC6H3(CH3)OH
Número CAS:
Peso molecular:
150.22
Número FEMA:
2245
Beilstein:
1860514
Número CE:
Conselho da Europa nº:
2055
Número MDL:
Código UNSPSC:
12164502
ID de substância PubChem:
Número de Flavis:
4.031
NACRES:
NA.21

fonte biológica

synthetic

Nível de qualidade

grau

FG
Fragrance grade
Halal
Kosher

Agency

follows IFRA guidelines
meets purity specifications of JECFA

conformidade reg.

EU Regulation 1223/2009
EU Regulation 1334/2008 & 178/2002
FCC
FDA 21 CFR 117
FDA 21 CFR 172.515

Ensaio

≥98%

índice de refração

n20/D 1.522 (lit.)

pb

236-237 °C (lit.)

pf

3-4 °C (lit.)

densidade

0.976 g/mL at 20 °C (lit.)

aplicação(ões)

flavors and fragrances

Documentação

see Safety & Documentation for available documents

alérgeno alimentar

no known allergens

alérgeno de fragrância

no known allergens

Organoléptico

camphoraceous; woody; spicy

cadeia de caracteres SMILES

CC(C)c1ccc(C)c(O)c1

InChI

1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3

chave InChI

RECUKUPTGUEGMW-UHFFFAOYSA-N

Informações sobre genes

human ... UGT1A4(54657)

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Categorias relacionadas

Descrição geral

Carvacrol is a monoterpene compound that can be used as a flavoring agent in food and cosmetics. It is one of the major volatile components in oregano essential oil.

Aplicação


  • Carvacrol and Thymol Hybrids: Potential Anticancer and Antibacterial Therapeutics.: This review explores the synthesis, characterization, and biological activities of carvacrol and thymol hybrids, highlighting their potential as anticancer and antibacterial agents. The study emphasizes the significance of these compounds in developing novel therapeutic strategies (Peter et al., 2024).

  • Essential Oil Constituents as Anti-Inflammatory and Neuroprotective Agents: An Insight through Microglia Modulation.: This review investigates the role of essential oil constituents, including carvacrol, in modulating microglial activity. The findings suggest significant anti-inflammatory and neuroprotective effects, providing insights into their potential therapeutic applications in neuroinflammatory diseases (Stojanović et al., 2024).

  • Evidence of the Protective Role of Carvacrol in a Retinal Degeneration Animal Model.: This study demonstrates the protective effects of carvacrol in a retinal degeneration model. The results indicate that carvacrol can mitigate retinal damage and preserve retinal function, suggesting its potential as a therapeutic agent for retinal diseases (Inda et al., 2024).

  • Phytochemical Characterization and Biological Activities of Essential Oil from Satureja montana L., a Medicinal Plant Grown under the Influence of Fertilization and Planting Dates.: This study characterizes the essential oil of Satureja montana, rich in carvacrol, and evaluates its biological activities. The findings indicate significant antimicrobial and antioxidant properties, suggesting its potential in pharmaceutical and agricultural applications (Said-Al Ahl et al., 2024).

Exoneração de responsabilidade

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

Palavra indicadora

Danger

Frases de perigo

Classificações de perigo

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B

Código de classe de armazenamento

8A - Combustible, corrosive hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

212.0 °F

Ponto de fulgor (°C)

> 100 °C

Equipamento de proteção individual

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


Certificados de análise (COA)

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Supelco

Supelco

CRM40188

Thymol solution

Thymol European Pharmacopoeia (EP) Reference Standard

T1350000

Thymol

Sigma-Aldrich

Sigma-Aldrich

W306509

Thyme oil

Thymol analytical standard

Supelco

72477

Thymol

Eugenol natural, ≥98%, FG

Sigma-Aldrich

W246719

Eugenol

Carvacrol methyl ether phyproof® Reference Substance

PHL83363

Carvacrol methyl ether

Antimicrobial activity of carvacrol: current progress and future prospectives
Nostro A & Papalia T
Recent Patents on Anti-Cancer Drug Discovery, 7(1), 28-35 (2012)
The natural antimicrobial carvacrol inhibits Campylobacter jejuni motility and infection of epithelial cells
Van Alphen LB, et al
PLoS ONE, 7(9), e45343-e45343 (2012)
Yuhua Chang et al.
Journal of agricultural and food chemistry, 61(37), 8906-8913 (2013-09-04)
A simple cost-effective method (spontaneous emulsification) for fabricating physically stable antimicrobial nanoemulsions from essential oils is described. These nanoemulsions (10 wt % total oil phase) were formed by titration of a mixture of essential oil (carvacrol), carrier oil (medium chain
Bo Tang et al.
Oncogene, 38(20), 3946-3961 (2019-01-30)
Although VPAC1 and its ligand vasoactive intestinal peptide (VIP) are important in gastrointestinal physiology, their involvements in progression of gastrointestinal tumor have not been explored. Here, we found that higher expression of VIP/VPAC1 was observed in gastric cancer compared to
Wei-Zhe Liang et al.
Toxicology, 303, 152-161 (2012-11-14)
Carvacrol is one of the main substances of essential oil which triggers intracellular Ca(2+) mobilization and causes cytotoxicity in diverse cell models. However, the mechanism of carvacrol-induced Ca(2+) movement and cytotoxicity is not fully understood. This study examined the effect

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