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P1781

Sigma-Aldrich

Pteroic acid

≥93%

Sinônimo(s):

4-{[(2-Amino-4-hydroxypteridin-6-yl)methyl]amino}benzoic acid

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About This Item

Fórmula empírica (Notação de Hill):
C14H12N6O3
Número CAS:
119-24-4
Peso molecular:
312.28
Número MDL:
MFCD00075823
Código UNSPSC:
12352100
ID de substância PubChem:
57654505
NACRES:
NA.22

Nível de qualidade

200

Ensaio

≥93%

Formulário

powder

cadeia de caracteres SMILES

NC1=NC(=O)C2=NC(CNc3ccc(cc3)C(O)=O)=CNC2=N1

InChI

1S/C14H12N6O3/c15-14-19-11-10(12(21)20-14)18-9(6-17-11)5-16-8-3-1-7(2-4-8)13(22)23/h1-4,6,16H,5H2,(H,22,23)(H3,15,17,19,20,21)

chave InChI

JOAQINSXLLMRCV-UHFFFAOYSA-N

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Aplicação

Pteroic acid can be used as a reactant to synthesize:
  • N-trifluoroacetyl pteroic acid by reacting with trifluoroacetic anhydride via acylation.
  • bis-Decyl chain derivative of pteroic acid through photocleavage reaction.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
BCCH0300
BCCF1193
BCCC3033
BCBZ5374
BCBV9816

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M1000008

Methotrexate impurity D

2,4-Diamino-6-(hydroxymethyl)pteridine 95%

Sigma-Aldrich

861634

2,4-Diamino-6-(hydroxymethyl)pteridine

Folic acid impurity A European Pharmacopoeia (EP) Reference Standard

Y0001242

Folic acid impurity A

Folate binding protein from bovine milk lyophilized powder

Sigma-Aldrich

F0504

Folate binding protein from bovine milk

Thiochrome analytical standard

Supelco

T7891

Thiochrome

Ácido fólico ≥97%

Sigma-Aldrich

F7876

Ácido fólico

7,8-Dihydro-L-biopterin ≥94% (HPLC)

Sigma-Aldrich

37272

7,8-Dihydro-L-biopterin

Fmoc-Glu-OtBu Novabiochem®

Sigma-Aldrich

8.52035

Fmoc-Glu-OtBu

4-Deoxypyridoxine hydrochloride analytical standard

Supelco

D0501

4-Deoxypyridoxine hydrochloride

R L Stephens et al.
The Journal of pharmacology and experimental therapeutics, 239(3), 627-633 (1986-12-01)
Folic acid (FA) and 5-formyltetrahydrofolic acid (FTHF) have been shown previously to produce a marked stimulation of locomotor activity after bilateral injection into the rat nucleus accumbens. This study was designed to determine whether the hypermotility response produced by the
M J Akhtar et al.
Journal of pharmaceutical and biomedical analysis, 16(1), 95-99 (1998-02-03)
A high performance liquid chromatographic procedure was developed to determine folic acid and its photodegradation products, p-aminobenzoic acid, pterine-6-carboxylic acid, p-aminobenzoyl-L-glutamic acid, and pteroic acid in the presence of riboflavin. The method involves reversed phase, paired-ion chromatography on mu-BondaPak C18
H Oe et al.
Journal of nutritional science and vitaminology, 29(5), 523-531 (1983-10-01)
A sensitive radioassay method has been developed to quantitate the activity of the folate-hydrolyzing enzyme which catalyzes the hydrolysis of folic acid to pteroic acid and glutamic acid. The method is based on analyzing [2-14C]pteroic acid separated by a thin-layer
Kerim Babaoglu et al.
Structure (London, England : 1993), 12(9), 1705-1717 (2004-09-03)
Dihydropterate synthase (DHPS) is the target for the sulfonamide class of antibiotics, but increasing resistance has encouraged the development of new therapeutic agents against this enzyme. One approach is to identify molecules that occupy the pterin binding pocket which is
H S Tillinghast et al.
Journal of cell science, 87 ( Pt 1), 45-53 (1987-02-01)
Following a previous study indicating a sensitivity to folate during the developmental phase of Dictyostelium discoideum, a series of pteridines were investigated for their ability to induce amoebal chemotaxis during development of this organism. Several compounds were found to resemble
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