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Documentos Principais

F0504

Sigma-Aldrich

Folate binding protein from bovine milk

lyophilized powder

Sinônimo(s):

Folate Protein

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About This Item

Número MDL:
MFCD00131098
Código UNSPSC:
12352202
NACRES:
NA.61

fonte biológica

bovine milk

Nível de qualidade

200

forma

lyophilized powder

uso

1 mg sufficient for ~4,000 assays

composição

Protein, 20-40% modified Warburg-Christian

técnica(s)

ligand binding assay: suitable
surface plasmon resonance (SPR): suitable

capacidade

1.5-6.0 μg/mg, protein binding capacity (folic acid)(25 °C at pH 7.5.)

temperatura de armazenamento

−20°C

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Aplicação

Folate binding protein can be used in radioligand binding assays of serum folate. The folate receptor has been used in studies as a therapeutic target in a variety of cancers.
Folate binding protein from bovine milk has been used in folate binding studies using surface plasmon resonance and in the uptake studies in kidney proximal tubule cells.
Useful for radioligand binding assays of serum folate. May also bind N-methyltetrahydrofolic acid and other folate analogues.

Ações bioquímicas/fisiológicas

Folate-binding protein (FBP) is present as a cell receptor and binds to folate in equimolar ratio. It is involved in the transport of folate and improves their bioavailability.

Embalagem

Package size based on protein content

Qualidade

Purified over 1,000 fold. May contain a trace of β-mercaptoethanol.

forma física

Lyophilized powder containing buffer salt as sodium citrate

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Ácido fólico BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥97%

Sigma-Aldrich

F8758

Ácido fólico

Dietary interactions influence the effects of bovine folate-binding protein on the bioavailability of tetrahydrofolates in rats
Jones ML, et al.
The Journal of Nutrition, 133(2), 489-495 (2003)
Radioisotopic assay for measurement of serum folate levels.
S Waxman et al.
Blood, 38(2), 219-228 (1971-08-01)
Radioassay of serum folate.
R T Dunn et al.
Clinical chemistry, 19(10), 1101-1105 (1973-10-01)
Martin D Forster et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 71(11), 945-950 (2007-08-23)
The alpha-folate receptor (alpha-FR) is a folate transporter with restricted expression levels in normal tissues. It is over-expressed in several cancers, particularly epithelial carcinomas, including nonmucinous ovarian carcinoma. It offers a novel therapeutic target for selective imaging and cytotoxic agents.
LRP2 mediates folate uptake in the developing neural tube
Kur E, et al.
Journal of Cell Science, jcs-140145 (2014)
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