920665

2-(1-(1-(tert-Butoxycarbonyl)piperidin-3-yl)-1H-pyrazol-4-yl)acetic acid

• Sinônimo(s): Rigid linker for PROTAC^® development
• Fórmula empírica (Notação de Hill): C₁₅H₂₃N₃O₄
• Número CAS: 1781095-18-8
• Peso molecular: 309.36
• Código UNSPSC: 12352106
• NACRES: NA.22

Propriedades

• adequação da reação: reagent type: linker
• Nível de qualidade: 100
• grupo funcional: Boc; carboxylic acid
• cadeia de caracteres SMILES: CC(C)(OC(N1CCCC(N2C=C(C=N2)CC(O)=O)C1)=O)C

Descrição

Aplicação

2-(1-(1-(tert-Butoxycarbonyl)piperidin-3-yl)-1H-pyrazol-4-yl)acetic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920533
920649
920673
920703

Outras notas

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Practum is a registered trademark of Sartorius Lab Instruments GmbH & Co. KG

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable