907375

H-L-Photo-methionine HCl

≥95%

• Sinônimo(s): (S)-2-Amino-4-(3-methyl-3H-diazirin-3-yl)butanoic acid hydrochloride, (S)-2-Amino-4-(3H-diazirin-3-yl)pentanoic acid hydrochloride, Diazirine amino acid, Photo-Met, Photo-crosslinking amino acid, Photoprobe building block
• Fórmula empírica (Notação de Hill): C₆H₁₂ClN₃O₂
• Número CAS: 851960-68-4
• Peso molecular: 193.63
• Código UNSPSC: 12352209

Propriedades

• Ensaio: ≥95%
• forma: powder
• adequação da reação: reaction type: solution phase peptide synthesis
• disponibilidade: available only in USA
• aplicação(ões): peptide synthesis
• temperatura de armazenamento: 2-8°C

Descrição

Aplicação

H-L-Photo-Methionine HCl is a diazirine-containing methionine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (~360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An Fmoc-protected version is also available as 907367.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

Outras notas

Carboxyl-Photo-Reactive MS-Cleavable Cross-Linkers: Unveiling a Hidden Aspect of Diazirine-Based Reagents

A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancer

Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes

Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe

Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

Informações de segurança

• Pictogramas: GHS02
• Palavra indicadora: Danger
• Frases de perigo: H242
• Declarações de precaução: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Classificações de perigo: Self-react. C
• Código de classe de armazenamento: 5.2 - Organic peroxides and self-reacting hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable