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677175

Sigma-Aldrich

Pyruvic-1-13C acid

≥99 atom % 13C, ≥99% (CP)

Sinônimo(s):

α-Ketopropionic acid-1-13C, 2-Oxopropionic acid-1-13C, 13C Labeled pyruvic acid, Pyruvic acid-1-13C

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About This Item

Fórmula linear:
CH3CO13CO2H
Número CAS:
99124-30-8
Peso molecular:
89.05
Número MDL:
MFCD10566986
Código UNSPSC:
12352106
ID de substância PubChem:
329760673
NACRES:
NA.12

pureza isotópica

≥99 atom % 13C

Nível de qualidade

200

Ensaio

≥99% (CP)

pb

165 °C

pf

11-12 °C

densidade

1.281 g/mL at 25 °C

alteração de massa

M+1

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CC(=O)[13C](O)=O

InChI

1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/i3+1

chave InChI

LCTONWCANYUPML-LBPDFUHNSA-N

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Descrição geral

Pyruvic-1-13C is isotopic labeled precursor of pyruvic acid.

Aplicação

Hyperpolarized 13C-labeled pyruvate and its metabolite lactate has been used to image real time metabolic flux in solid tumors and assess tumor response to chemotherapy, radiation, and agents targeting mTOR.

Embalagem

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Pictogramas

Corrosion
GHS05

Palavra indicadora

Danger

Frases de perigo

H314

Classificações de perigo

Eye Dam. 1 - Skin Corr. 1C

Código de classe de armazenamento

8A - Combustible corrosive hazardous materials

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

179.6 °F - closed cup

Ponto de fulgor (°C)

82 °C - closed cup

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Certificados de análise (COA)

Lot/Batch Number
MBBD2813
MBBD1214
MBBC8002
MBBC4409
MBBC6541

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Ilwoo Park et al.
Journal of magnetic resonance imaging : JMRI, 33(6), 1284-1290 (2011-05-19)
To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model. Twenty athymic rats with intracranial implantation of human glioblastoma cells were divided into two groups: one
Mette Hauge Lauritzen et al.
NMR in biomedicine, 26(11), 1496-1500 (2013-06-25)
A change in myocardial metabolism is a known effect of several diseases. MRS with hyperpolarized (13)C-labelled pyruvate is a technique capable of detecting changes in myocardial pyruvate metabolism, and has proven to be useful for the evaluation of myocardial ischaemia
Prasanta Dutta et al.
Cancer research, 73(14), 4190-4195 (2013-06-01)
Hyperpolarized (13)C magnetic resonance spectroscopy provides a unique opportunity to detect real-time metabolic fluxes as a means to measure metabolic treatment responses in vivo. Here, we show that pharmacologic inhibition of lactate dehydrogenase-A suppressed the conversion of hyperpolarized (13)C-pyruvate to
Albert P Chen et al.
Magnetic resonance in medicine, 73(6), 2087-2093 (2014-07-22)
Hyperpolarized [1-(13) C]lactate in solution may be a clinically relevant and safe substrate for real time MR investigations of key metabolic pathways. The potential of using hyperpolarized [1-(13) C]lactate for magnetic resonance studies of cardiac metabolism in vivo was explored.

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