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W6578

Sigma-Aldrich

Pyruvic-1-13C acid

API for Clinical Studies, ≥99 atom % 13C

Sinônimo(s):

α-Ketopropionic acid-1-13C, 2-Oxopropionic acid-1-13C, 13C Labeled pyruvic acid, Pyruvic acid-1-13C

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About This Item

Fórmula linear:
CH3CO13CO2H
Número CAS:
99124-30-8
Peso molecular:
89.05
Número MDL:
MFCD10566986
Código UNSPSC:
12352106
ID de substância PubChem:
329830758
NACRES:
NA.12

grau

cGMP

Nível de qualidade

400

pureza isotópica

≥99 atom % 13C

Ensaio

≥95% (CP)

Formulário

viscous liquid

p.e.

165 °C

pf

11-12 °C

alteração de massa

M+1

Condições de expedição

dry ice

temperatura de armazenamento

-10 to -25°C

cadeia de caracteres SMILES

CC(=O)[13C](O)=O

InChI

1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/i3+1

chave InChI

LCTONWCANYUPML-LBPDFUHNSA-N

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Descrição geral

Pyruvic-1-13C is isotopic labeled precursor of pyruvic acid.

Aplicação

Hyperpolarized 13C-labeled pyruvate and its metabolite lactate has been used to image real time metabolic flux in solid tumors and assess tumor response to chemotherapy, radiation, and agents targeting mTOR.

Embalagem

Typically, this product is available to ship immediately from stock. Contact Stable Isotopes Customer Service to discuss quantity and packaging needs.

Pictogramas

Corrosion
GHS05

Palavra indicadora

Danger

Frases de perigo

H314

Classificações de perigo

Eye Dam. 1 - Skin Corr. 1C

Código de classe de armazenamento

8A - Combustible corrosive hazardous materials

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

179.6 °F - closed cup

Ponto de fulgor (°C)

82 °C - closed cup

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
MBBD2752
MBBC8639
MBBC6060
MBBC7230
MBBC1551

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490717

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8.20170

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Pyruvic acid 98%

Sigma-Aldrich

107360

Pyruvic acid

Ilwoo Park et al.
Journal of magnetic resonance imaging : JMRI, 33(6), 1284-1290 (2011-05-19)
To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model. Twenty athymic rats with intracranial implantation of human glioblastoma cells were divided into two groups: one
Mette Hauge Lauritzen et al.
NMR in biomedicine, 26(11), 1496-1500 (2013-06-25)
A change in myocardial metabolism is a known effect of several diseases. MRS with hyperpolarized (13)C-labelled pyruvate is a technique capable of detecting changes in myocardial pyruvate metabolism, and has proven to be useful for the evaluation of myocardial ischaemia
Prasanta Dutta et al.
Cancer research, 73(14), 4190-4195 (2013-06-01)
Hyperpolarized (13)C magnetic resonance spectroscopy provides a unique opportunity to detect real-time metabolic fluxes as a means to measure metabolic treatment responses in vivo. Here, we show that pharmacologic inhibition of lactate dehydrogenase-A suppressed the conversion of hyperpolarized (13)C-pyruvate to
Albert P Chen et al.
Magnetic resonance in medicine, 73(6), 2087-2093 (2014-07-22)
Hyperpolarized [1-(13) C]lactate in solution may be a clinically relevant and safe substrate for real time MR investigations of key metabolic pathways. The potential of using hyperpolarized [1-(13) C]lactate for magnetic resonance studies of cardiac metabolism in vivo was explored.

Artigos

Dynamic Nuclear Polarization

Dynamic Nuclear Polarization (DNP) is a phenomenon by which high spin polarization, typically derived from a bath of free radical electrons, is transferred to a nuclear spin bath, enhancing the difference between the nuclear energy levels and thereby producing dramatically enhanced NMR signals for detection.

MRI/MRS: Use of Isotopes in Hyperpolarization

Sigma-Aldrich.com presents an article concerning MRI/MRS and the use of isotopes in hyperpolarization.

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