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Sigma-Aldrich

(Bromomethyl)cyclobutane

97%

Sinônimo(s):

Cyclobutylmethyl bromide

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About This Item

Fórmula linear:
C4H7CH2Br
Número CAS:
17247-58-4
Peso molecular:
149.03
Número MDL:
MFCD00040960
Código UNSPSC:
12352100
ID de substância PubChem:
24867336
NACRES:
NA.22

Ensaio

97%

forma

liquid

índice de refração

n20/D 1.48 (lit.)

pb

123-124 °C (lit.)

densidade

1.326 g/mL at 25 °C (lit.)

cadeia de caracteres SMILES

BrCC1CCC1

InChI

1S/C5H9Br/c6-4-5-2-1-3-5/h5H,1-4H2

chave InChI

FLHFTXCMKFVKRP-UHFFFAOYSA-N

Categorias relacionadas

Descrição geral

(Bromomethyl)cyclobutane (bromomethyl-cyclobutane) is an aryl fluorinated building block. Its reaction with various hydroxychromen-4-one derivatives in the presence of anhydrous K2CO3/dry acetone and Bu4N+I- (PTC) has been investigated.

Aplicação

(Bromomethyl)cyclobutane may be used in the synthesis of racemic 3-cyclobutylalanine and 17-(cyclobutylmethyl)morphinan-3-ol (butorphan).

Pictogramas

Flame
GHS02

Palavra indicadora

Warning

Frases de perigo

H226

Declarações de precaução

P210 - P233 - P240 - P241 - P242 - P243

Classificações de perigo

Flam. Liq. 3

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

105.8 °F - closed cup

Ponto de fulgor (°C)

41 °C - closed cup

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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The phenolic group of the potent mu and kappa opioid morphinan agonist/antagonists cyclorphan and butorphan was replaced by phenylamino and benzylamino groups including compounds with para-substituents in the benzene ring. These compounds are highly potent mu and kappa ligands, e.g.
Markus Nett et al.
Journal of medicinal chemistry, 52(19), 6163-6167 (2009-09-15)
The natural proteasome inhibitor salinosporamide A from the marine bacterium Salinispora tropica is a promising drug candidate for the treatment of multiple myeloma and mantle cell lymphoma. Using a comprehensive approach that combined chemical synthesis with metabolic engineering, we generated
Ao Zhang et al.
Journal of medicinal chemistry, 47(1), 165-174 (2003-12-30)
A series of 10-ketomorphinan analogues were synthesized, and their binding affinity at all three opioid receptors was investigated. In most cases, high affinity at micro and kappa receptors, and lower affinity at delta receptor was observed, resulting in good selectivity
Cyclopropylmethyl-and cyclobutylmethyllithium by an arene-catalyzed lithiation. Stability and reactivity.
Pe?afiel I, et al.
Tetrahedron, 66(16), 2928-2935 (2010)
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