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335673

Sigma-Aldrich

1-Dodecyl-2-pyrrolidinone

99%

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About This Item

Fórmula empírica (Notação de Hill):
C16H31NO
Número CAS:
2687-96-9
Peso molecular:
253.42
Número CE:
403-730-1
Número MDL:
MFCD00075066
Código UNSPSC:
12352100
ID de substância PubChem:
24860339
NACRES:
NA.22

Ensaio

99%

forma

viscous liquid

índice de refração

n20/D 1.466 (lit.)

pb

202-205 °C/11 mmHg (lit.)

densidade

0.89 g/mL at 25 °C (lit.)

cadeia de caracteres SMILES

CCCCCCCCCCCCN1CCCC1=O

InChI

1S/C16H31NO/c1-2-3-4-5-6-7-8-9-10-11-14-17-15-12-13-16(17)18/h2-15H2,1H3

chave InChI

NJPQAIBZIHNJDO-UHFFFAOYSA-N

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Descrição geral

1-Dodecyl-2-pyrrolidinone is an N-alkyl lactam and its reduction with LiH3BNMe2 to the corresponding amine has been reported. It is a potential melatonin-specific chemical penetration enhancer.

Aplicação

1-Dodecyl-2-pyrrolidinone was used in the preparation of few-layered flakes of molybdenum disulfide (MoS2) via liquid phase exfoliation of bulk MoS2 powder.

Palavra indicadora

Danger

Frases de perigo

H314,H317,H410

Classificações de perigo

Aquatic Acute 1 - Aquatic Chronic 1 - Skin Corr. 1B - Skin Sens. 1

Código de classe de armazenamento

8A - Combustible corrosive hazardous materials

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

235.4 °F - closed cup

Ponto de fulgor (°C)

113 °C - closed cup

Equipamento de proteção individual

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
MKCM0898
MKBZ4498V
MKBJ2361V
MKBH4471V
MKBF6943V

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1-metil-2-pirrolidinona anhydrous, 99.5%

Sigma-Aldrich

328634

1-metil-2-pirrolidinona

N,N-Dimetildodecilamina-N-óxido BioXtra, ≥99.0% (NT)

Sigma-Aldrich

40234

N,N-Dimetildodecilamina-N-óxido

1-metil-2-pirrolidinona ACS reagent, ≥99.0%

Sigma-Aldrich

443778

1-metil-2-pirrolidinona

S Sato et al.
Chemical & pharmaceutical bulletin, 46(5), 831-836 (1998-06-11)
The enhancing effects of N-dodecyl-2-pyrrolidone (NDP) on the percutaneous absorption of doxifluridine (DOX), 5-fluorouracil (5-FU), tegafur (TEG) and carmofur (CAR) were examined using an in vitro penetration technique and rat skin. Phosphate buffered isotonic saline (PBS), propylene glycol (PG) and
Andrew Winchester et al.
ACS applied materials & interfaces, 6(3), 2125-2130 (2014-01-22)
We report on the electrochemical charge storage behavior of few-layered flakes of molybdenum disulfide (MoS2) obtained by liquid phase exfoliation of bulk MoS2 powder in 1-dodecyl-2-pyrrolidinone. The specific capacitances of the exfoliated flakes obtained using a 6 M KOH aqueous
Srinivas S Godavarthy et al.
Journal of pharmaceutical sciences, 98(11), 4085-4099 (2009-08-22)
One promising way to breach the skin's natural barrier to drugs is by the application of chemicals called penetration enhancers. However, identifying potential enhancers is difficult and time consuming. We have developed a virtual screening algorithm for generating potential chemical
Vijay Krishna Rachakonda et al.
Pharmaceutical research, 25(11), 2697-2704 (2008-08-07)
A novel technique is presented for identifying potential chemical penetration enhancers (CPEs) based on changes in the electrical resistance of skin. Specifically, a multi-well resistance chamber was designed and constructed to facilitate more rapid determination of the effect of CPEs
H Sasaki et al.
The Journal of pharmacy and pharmacology, 42(3), 196-199 (1990-03-01)
The enhancing effect of combining 1-methyl-2-pyrrolidone (MP) and 1-lauryl-2-pyrrolidone (LP) as the vehicles for transdermal penetration of phenolsulphonphthalein (phenol red) has been investigated by using an in-vitro technique with excised rat skin. LP had a higher enhancing effect on the
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