270 °C (lit.)
DNA synthesis | interferes
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Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
This information can be found on the MSDS Section 11.
Sterile solutions in 0.9% sodium chloride protected from light are stable for 28 days at room temperature.
Pharmaceutical injections of cisplatin are in 0.9% sodium chloride at 1 mg/ml. A 0.1% solution in 0.9% sodium chloride solution has a pH range of 4.5-6.0 immediately after preparation and can be adjusted with HCl.
At 37 °C, the half-life of cisplatin in DMSO is 60 minutes. In vivo the half-life of cisplatin is approximately 30 minutes.
The divalent platinum has a high affinity for sulfur donor ligands and this will displace the chloride. The use of DMSO as a solvent affects the instability of cisplatin and can affect biological activity. Sundquist, W. I., et al., Inorg. Chem. 26:1524-1528, 1987.
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We presents an article on ABC Transporters and Cancer Drug Resistance
Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of multicellular organisms, apoptosis is tightly regulated through two principal pathways by a number of regulatory and effector molecules.
n proliferating cells, the cell cycle consists of four phases. Gap 1 (G1) is the interval between mitosis and DNA replication that is characterized by cell growth. Replication of DNA occurs during the synthesis (S) phase, which is followed by a second gap phase (G2) during which growth and preparation for cell division occurs. Together, these three stages comprise the interphase phase of the cell cycle. Interphase is followed by the mitotic (M) phase.