P3292

Sigma-Aldrich

Pancreatin from porcine pancreas

powder, suitable for cell culture, 4 × USP specifications

Synonym(s):
Pancreatin from hog pancreas
CAS Number:
EC Number:
MDL number:
NACRES:
NA.75

biological source

Porcine pancreas

Quality Level

Agency/Method

USP (specifications)

form

powder

specific activity

4 × USP specifications

contains

lactose or sucrose as extender (The sucrose used might contain up to 3.25% starch.)

application(s)

cell culture | mammalian: suitable

shipped in

ambient

storage temp.

−20°C

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Related Categories

Packaging

25, 100 g in poly bottle

Application

Pancreatin from porcine pancreas has been used to assess the treatment of steatorrhea by lipase supplementation therapy, to investigate treatment options for pancreatic diabetes in patients experiencing the decompensated stage of chronic pancreatitis, and to safely and effectively remove formalin-fixed tissues from arterial grafts without leading to structural damage or loss in fiber integrity.

Biochem/physiol Actions

Pancreatin contains enzymatic components including trypsin, amylase and lipase, ribonuclease, and protease, produced by the exocrine cells of the porcine pancreas. This combination of enzymes allows it to hydrolyze proteins, starch and fats. Pancreatin will convert not less than 25 times its weight of potato starch into soluble carbohydrates in 5 minutes in water at 40°C, will digest not less than 25 times its weight of casein in 60 minutes at pH 7.5 at 40°C and will release not less than microequivalents of acid per min per mg pancreatin from olive oil at pH 9.0 at 37°C.

Pictograms

Exclamation markHealth hazard

Signal Word

Danger

hazcat

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 1

Certificate of Analysis

Certificate of Origin

Xu-Dong Kong et al.
Nature biomedical engineering, 4(5), 560-571 (2020-05-13)
The oral administration of peptide drugs is hampered by their metabolic instability and limited intestinal uptake. Here, we describe a method for the generation of small target-specific peptides (less than 1,600 Da in size) that resist gastrointestinal proteases. By using...
C Giromini et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 34(8), 1436-1445 (2017-04-12)
Ex-food or former food products (FFPs) have been proposed as one of the categories with great promise as alternative feed ingredients. FFPs' nutritional potential is not yet fully exploited. Therefore, the aim of this study was to perform a nutritional...
Bruna Maria Salotti de Souza et al.
Probiotics and antimicrobial proteins, 11(2), 382-396 (2018-03-16)
The objective of this study was to evaluate the probiotic properties of Lactobacillus casei and Lactobacillus fermentum strains, as well as to select novel and safe strains for future development of functional fermented products. The in vitro auto-aggregation, co-aggregation, hydrophobicity...
Matthew T Pereira et al.
Disease models & mechanisms, 11(12) (2018-12-07)
Increased intestinal barrier permeability has been correlated with aging and disease, including type 2 diabetes, Crohn's disease, celiac disease, multiple sclerosis and irritable bowel syndrome. The prevalence of these ailments has risen together with an increase in industrial food processing...
C M Seiler et al.
Alimentary pharmacology & therapeutics, 37(7), 691-702 (2013-02-07)
Pancreatic exocrine insufficiency (PEI) often occurs following pancreatic surgery. To demonstrate the superior efficacy of pancreatin 25 000 minimicrospheres (Creon 25000 MMS; 9-15 capsules/day) over placebo in treating PEI after pancreatic resection. A 1-week, double-blind, randomised, placebo-controlled, parallel-group, multicentre study with...

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