MilliporeSigma
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T9159

Sigma-Aldrich

Trichloroacetic acid

BioXtra, ≥99.0%

Synonym(s):
TCA
Linear Formula:
Cl3CCOOH
CAS Number:
Molecular Weight:
163.39
Beilstein:
970119
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NB.22

vapor density

<1 (vs air)

Quality Level

vapor pressure

1 mmHg ( 51 °C)

product line

BioXtra

assay

≥99.0%

impurities

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

ign. residue

≤0.03%

refractive index

n20/D 1.62 (lit.)

bp

196 °C (lit.)

mp

54-58 °C (lit.)

solubility

H2O: 0.5 M at 20 °C, clear, colorless

density

1.62 g/mL at 25 °C (lit.)

anion traces

sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.005%
Cu: ≤0.0005%
Fe: ≤0.001%
K: ≤0.01%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

storage temp.

2-8°C

SMILES string

OC(=O)C(Cl)(Cl)Cl

InChI

1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChI key

YNJBWRMUSHSURL-UHFFFAOYSA-N

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General description

Trichloroacetic acid (TCA) is an important metabolic product of trichloroethylene (TCE) metabolism.

Application

Trichloroacetic acid has been used:
  • for protein precipitation
[86]
  • as a component in the extract solution used for the measurement of malondialdehyde and glutathione
  • [87]
  • to precipitate the transfected and treated cells in [3H]-thymidine incorporation assay
  • [88]
    Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.

    Packaging

    100, 250, 500 g in glass bottle

    Biochem/physiol Actions

    TCA might act as a carcinogen, targeting liver.[57] It might be used as an acid decalcifying agent. TCA helps in nuclear staining.[85]

    Pictograms

    CorrosionEnvironment

    Signal Word

    Danger

    Hazard Statements

    Hazard Classifications

    Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A

    Storage Class Code

    8B - Non-combustible, corrosive hazardous materials

    WGK

    WGK 2

    Flash Point(F)

    235.4 °F - closed cup

    Flash Point(C)

    > 113 °C - closed cup

    Personal Protective Equipment

    dust mask type N95 (US), Eyeshields, Gloves

    Certificate of Analysis

    Enter Lot Number to search for Certificate of Analysis (COA).

    Certificate of Origin

    Enter Lot Number to search for Certificate of Origin (COO).

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