N5410

Nicotinic acid

meets USP testing specifications

• Synonym(s): 3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B₃
• Empirical Formula (Hill Notation): C₆H₅NO₂
• CAS Number: 59-67-6
• Molecular Weight: 123.11
• Beilstein: 109591
• EC Number: 200-441-0
• MDL number: MFCD00006391
• PubChem Substance ID: 24897734
• NACRES: NA.21

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• Agency: USP/NF; meets USP testing specifications
• assay: 99.0-101.0% dry basis
• form: powder
• color: white
• mp: 236-239 °C (lit.)
• application(s): pharmaceutical (small molecule)
• SMILES string: OC(=O)c1cccnc1
• InChI: 1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
• InChI key: PVNIIMVLHYAWGP-UHFFFAOYSA-N
• Gene Information: human ... CYP1A2(1544) ; rat ... Chrnb2(54239)

Description

General description

Nicotinic acid, also referred to as niacin or as vitamin B₃[54], is a water-soluble vitamin.[55] Nicotinic acid is synthesized from the amino acid tryptophan and is present majorly in peanuts, fish and lean meat.[56]

Application

Nicotinic acid has been used as an antioxidant to evaluate its protective functionality in colon LoVo cell lines against doxorubicin induced cytotoxicity.[78]

Biochem/physiol Actions

Nicotinic modulates lipid metabolism and may be useful in treating dyslipidemia.[54] It is an antioxidant and acts as a coenzyme in the form of nicotinamide adenine nucleotides.[56] Deficiency of niacin leads to enhanced lipid peroxidation and is also implicated in Crohn′s disease[56] Deficiency also impacts DNA repair[59] and also leads to skin and gastrointestinal disorder, pellagra.[76] Nicotinic acid reduces the low-density lipoprotein (LDL) synthesis and improves high-density lipoprotein (HDL) levels.[57]

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319
• Precautionary Statements: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): 379.4 °F - closed cup
• Flash Point(C): 193 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves