N5410

Nicotinic acid

meets USP testing specifications

• Synonym(s): Pellagra preventive factor, Niacin, Pyridine-3-carboxylic acid, Vitamin B₃, 3-Picolinic acid
• Empirical Formula (Hill Notation): C₆H₅NO₂
• CAS Number: 59-67-6
• Molecular Weight: 123.11
• Beilstein: 109591
• EC Number: 200-441-0
• MDL number: MFCD00006391
• PubChem Substance ID: 24897734
• NACRES: NA.21

Properties

• Quality Level: 200
• biological source: synthetic (organic)
• Agency: USP/NF; meets USP testing specifications
• assay: 99.0-101.0% dry basis
• form: powder
• color: white
• mp: 236-239 °C (lit.)
• application(s): pharmaceutical (small molecule)
• SMILES string: OC(=O)c1cccnc1
• InChI: 1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
• InChI key: PVNIIMVLHYAWGP-UHFFFAOYSA-N
• Gene Information: human ... CYP1A2(1544) ; rat ... Chrnb2(54239)

Description

General description

Nicotinic acid, also referred to as niacin or as vitamin B₃, is a water-soluble vitamin. Nicotinic acid is synthesized from the amino acid tryptophan and is present majorly in peanuts, fish and lean meat.

Application

Nicotinic acid has been used as an antioxidant to evaluate its protective functionality in colon LoVo cell lines against doxorubicin induced cytotoxicity.

Biochem/physiol Actions

Nicotinic modulates lipid metabolism and may be useful in treating dyslipidemia. It is an antioxidant and acts as a coenzyme in the form of nicotinamide adenine nucleotides. Deficiency of niacin leads to enhanced lipid peroxidation and is also implicated in Crohn′s disease Deficiency also impacts DNA repair and also leads to skin and gastrointestinal disorder, pellagra. Nicotinic acid reduces the low-density lipoprotein (LDL) synthesis and improves high-density lipoprotein (HDL) levels.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319
• Precautionary Statements: P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): 379.4 °F - closed cup
• Flash Point(C): 193 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves