MilliporeSigma
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N5410

Sigma-Aldrich

Nicotinic acid

meets USP testing specifications

Synonym(s):
3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B3
Empirical Formula (Hill Notation):
C6H5NO2
CAS Number:
Molecular Weight:
123.11
Beilstein:
109591
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

biological source

synthetic (organic)

Quality Level

Agency

USP/NF
meets USP testing specifications

assay

99.0-101.0% dry basis

form

powder

color

white

mp

236-239 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

OC(=O)c1cccnc1

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

InChI key

PVNIIMVLHYAWGP-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544)
rat ... Chrnb2(54239)

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General description

Nicotinic acid, also referred to as niacin or as vitamin B3[54], is a water-soluble vitamin.[55] Nicotinic acid is synthesized from the amino acid tryptophan and is present majorly in peanuts, fish and lean meat.[56]

Application

Nicotinic acid has been used as an antioxidant to evaluate its protective functionality in colon LoVo cell lines against doxorubicin induced cytotoxicity.[78]

Biochem/physiol Actions

Nicotinic modulates lipid metabolism and may be useful in treating dyslipidemia.[54] It is an antioxidant and acts as a coenzyme in the form of nicotinamide adenine nucleotides.[56] Deficiency of niacin leads to enhanced lipid peroxidation and is also implicated in Crohn′s disease[56] Deficiency also impacts DNA repair[59] and also leads to skin and gastrointestinal disorder, pellagra.[76] Nicotinic acid reduces the low-density lipoprotein (LDL) synthesis and improves high-density lipoprotein (HDL) levels.[57]

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

379.4 °F - closed cup

Flash Point(C)

193 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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