47864

Nicotinic acid

analytical standard

• Synonym(s): 3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B₃
• Empirical Formula (Hill Notation): C₆H₅NO₂
• CAS Number: 59-67-6
• Molecular Weight: 123.11
• Beilstein: 109591
• EC Number: 200-441-0
• MDL number: MFCD00006391
• PubChem Substance ID: 24871534

Properties

• grade: analytical standard
• Quality Level: 100
• CofA: current certificate can be downloaded
• feature: standard type water soluble vitamin
• packaging: ampule of 1000 mg
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 236-239 °C (lit.)
• density: 1.473 g/cm³ at 25 °C
• application(s): pharmaceutical (small molecule); vitamins, nutraceuticals, and natural products
• format: neat
• storage temp.: 2-30°C
• SMILES string: OC(=O)c1cccnc1
• InChI: 1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
• InChI key: PVNIIMVLHYAWGP-UHFFFAOYSA-N
• Gene Information: human ... CYP1A2(1544) ; rat ... Chrnb2(54239)

Description

General description

Nicotinic acid acts as an antilipolytic drug in adipose tissue, and is commonly used for hyperlipoproteinaemia and pellagra.[95]

Nicotinic acid is a water soluble[22], vitamin belonging to B complex group of vitamins[20], which can be used as a broad spectrum lipid lowering drug.[21] Its mode of action basically involves the inhibition of the hormone-sensitive triglyceride lipase and thereby, decreasing the lipolysis in adipose tissue.[20][21]

Application

Nicotinic acid may be used as an analytical reference standard for the quantification of the analyte in tablet dosage forms using reversed-phase high-performance liquid chromatography technique.[95]

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319
• Precautionary Statements: P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): 379.4 °F - closed cup
• Flash Point(C): 193 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves