MilliporeSigma
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S5261

Sigma-Aldrich

Sodium selenite

BioReagent, suitable for cell culture, ≥98%

Synonym(s):
Sodium salt, Selenious acid
Linear Formula:
Na2SeO3
CAS Number:
Molecular Weight:
172.94
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.75

Quality Level

biological source

synthetic (inorganic)

product line

BioReagent

assay

≥98%

form

powder

technique(s)

cell culture | mammalian: suitable

mp

>350 °C (lit.)

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless

SMILES string

[Na+].[Na+].[O-][Se]([O-])=O

InChI

1S/2Na.H2O3Se/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2

InChI key

BVTBRVFYZUCAKH-UHFFFAOYSA-L

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Application

Sodium selenite is commonly used as a source of selenium in biological research, where selenium is an essential trace element that is normally provided by serum. Selenium is present in selenoproteins such as glutathione peroxidase and thioredoxin reductase, which contain the selenium analog of cysteine, selenocysteine. In particular, glutathione peroxidase has a role in detoxification in vivo as a scavenger of peroxides. Sodium selenite has been utilized in studies of cell proliferation and cancer research. It has been used to alter gene expression in HepG2 cells as analyzed by cDNA microarrays. Sodium selenite can inhibit zinc finger protein/DNA interactions. Sodium selenite has been shown to alter mitochondrial membrane potentials and thus potentially contribute to apoptosis.
This product is cell culture tested (0.005 mg/L) and is appropriate for use in cell culture applications.

Packaging

10, 25, 100 g in glass bottle

Pictograms

Skull and crossbonesEnvironment

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Supplementary Hazards

Storage Class Code

6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

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Simon P W Hageman et al.
Water research, 47(7), 2118-2128 (2013-03-15)
Removal of the toxic selenium compounds selenite and selenate from waste water before discharge is becoming increasingly imperative in industrialized countries. Bacteria can reduce selenate to selenite, but also further to elemental selenium, selenide or organic selenium. In this paper
Chih-Ching Yang et al.
PloS one, 9(7), e96006-e96006 (2014-07-02)
Deep-sea water (DSW), which is rich in micronutrients and minerals and with antioxidant and anti-inflammatory qualities, may be developed as marine drugs to provide intestinal protection against duodenal ulcers. We determined several characteristics in the modified DSW. We explored duodenal
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Aquatic toxicology (Amsterdam, Netherlands), 130-131, 97-111 (2013-02-07)
Selenium (Se) is an oligonutrient with both essential biological functions and recognized harmful effects. As the selenocysteine (SeCys) amino acid, selenium is integrated in several Se-containing proteins (selenoproteins), many of which are fundamental for cell homeostasis. Nevertheless, selenium may exert

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