T7875

Sigma-Aldrich

Thiourea

ReagentPlus®, ≥99.0%

Synonym(s):
Thiocarbamide, Sulfourea
Linear Formula:
NH2CSNH2
CAS Number:
Molecular Weight:
76.12
Beilstein/REAXYS Number:
605327
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

product line

ReagentPlus®

assay

≥99.0%

mp

170-176 °C (lit.)

SMILES string

NC(N)=S

InChI

1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)

InChI key

UMGDCJDMYOKAJW-UHFFFAOYSA-N

Gene Information

mouse ... Ephx2(13850)

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General description

Thiourea is an analogue of urea, containing sulphur.

Application

Thiourea has been used:
  • as a component in ice cold sample buffer for protein analysis
  • in intracellular extraction buffer for the extraction of soluble intracellular proteins
  • as a component of electrophoresis buffer

Chaotropic agent; strong denaturant. Increases solubility and recovery of proteins

Packaging

5, 100, 500 g in poly bottle
1 kg in poly bottle
5, 12 kg in poly drum

Biochem/physiol Actions

Thiourea is a free radical scavenger of the peroxide radical. It was shown to inhibit lipid peroxidation and ultraviolet (UV)-induced crosslinking of collagen. Bud dormancy in plants can be inhibited by thiourea, which is used as a growth stimulator. It is also known to be used in the treatment of hyperthyroidism.

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Signal Word

Warning

hazcat

Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 3

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Synergistic effects of glucose and ultraviolet irradiation on the physical properties of collagen
Ohan MP, et al.
Journal of Biomedical Materials Research, 60(3), 384-391 (2002)
Feline hypertrophic cardiomyopathy associated with the p. A31P Mutation in cMyBP-C is caused by production of mutated cMyBP-C with reduced binding to actin
Godiksen MTN, et al.
Open Journal of Veterinary Medicine, 3(02), 95-95 (2013)
Extraction of Intracellular and Cell Wall Proteins from Leaves and Roots of Harsh Hakea
Shane MW and Plaxton WC
Journal of Experimental Botany (2014)
Mechanism of the reduction of methylene blue by thiourea in aqueous acidic medium
Osunlaja AA
International Journal of ChemTech Research, 4(2), 609-617 (2012)
Protocol: Optimised methodology for isolation of nuclei from leaves of species in the Solanaceae and Rosaceae families
Sikorskaite S, et al.
Plant methods, 9(1), 31-31 (2013)
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