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A4034

Sigma-Aldrich

(+)-Sodium L-ascorbate

powder, BioReagent, suitable for cell culture

Synonym(s):
L(+)-Ascorbic acid sodium salt, Vitamin C sodium salt
Empirical Formula (Hill Notation):
C6H7NaO6
CAS Number:
Molecular Weight:
198.11
Beilstein:
3767246
EC Number:
MDL number:
eCl@ss:
34058010
PubChem Substance ID:
NACRES:
NA.75

biological source

synthetic (organic)

Quality Level

product line

BioReagent

assay

≥98%

form

powder

mol wt

Mw 135.13 g/mol

technique(s)

cell culture | mammalian: suitable
cell culture | plant: suitable

color

white to off-white

mp

220 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

SMILES string

[Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-]

InChI

1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1

InChI key

PPASLZSBLFJQEF-RXSVEWSESA-M

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General description

(+)-Sodium L-ascorbate (SA) is a potential antioxidant and is a derivative of vitamin C (L-ascorbic acid).[12][55] It is widely used as a food additive.[12] In addition, SA enhances growth retardation activity of bleomycin sulfate, R020-1724 (an inhibitor of cyclic nucleotide phosphodiesterase), prostaglandin E1 and sodium butyrate agents on neuroblastoma cells in culture.[14] Elevated levels of SA induces two-stage urinary bladder carcinogenesis in rats.[12] sodium L-ascorbate in combination with collagenogenesis inhibitors is used to treat dermal scars and keloids.[55]

Application

(+)-Sodium L-ascorbate has been used:
  • to produce H2O2 in cell culture media
[15][17]
  • as a reducing agent for a cell-permeable artificial electron donor, N,N,N′,N′-tetramethyl-p-phenylenediamine (TMPD)
  • [26]
  • to study its effect on production of collagen and elastic fibers in fibroblasts cultures derived from normal human skin and dermal fat
  • [55]
    Used for preparation of plant extracts; reductant for the isolation of chloroplasts.

    Packaging

    100, 500 g in poly bottle
    1 kg in poly bottle

    Biochem/physiol Actions

    Antioxidant

    Storage Class Code

    13 - Non Combustible Solids

    WGK

    WGK 1

    Personal Protective Equipment

    dust mask type N95 (US), Eyeshields, Gloves

    Certificate of Analysis

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    Certificate of Origin

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