8.20610

Glyoxal

(40% solution in water) for synthesis

• UNSPSC Code: 12352114
• NACRES: NA.22

Properties

• vapor pressure: 20.2 hPa ( 20 °C)
• Quality Level: 200
• autoignition temp.: 285 °C
• potency: 2000-5000 mg/kg LD₅₀, oral (Rat); >2000 mg/kg LD₅₀, skin (Rat)
• pH: 2-3 (20 °C in H₂O)
• bp: 104 °C/1013 hPa
• mp: -14 °C
• density: 1.27 g/cm³ at 20 °C
• storage temp.: 2-30°C

Description

Application

• HFIP-Mediated Multicomponent Reactions: Research demonstrates the use of HFIP (Hexafluoroisopropanol) in synthesizing pyrazole-linked thiazole derivatives, highlighting a new application in organic synthesis. Glyoxal is instrumental in the development of these multifunctional structures, contributing to advanced material design (Banerjee et al., 2024).


• Peptide Stapling in Protein Engineering: A study describes peptide stapling techniques using alpha-ketoaldehydes, which crosslink amines through glyoxal-modified linkers. This approach is pivotal in creating stable peptide structures for therapeutic applications (Guo et al., 2024).

Analysis Note

Assay (acidimetric): 39.0 - 41.0 %
Density (d 20 °C/ 4 °C): 1.266 - 1.271

Safety Information

• pictograms: GHS05,GHS07,GHS08
• signalword: Danger
• hcodes: H314 - H317 - H335 - H341
• pcodes: P202 - P261 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Muta. 2 - Skin Corr. 1 - Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 8A - Combustible, corrosive hazardous materials
• wgk_germany: WGK 1