Sodium trichloroacetate with trichloroacetic acid (TCA) undergoes rapid decarboxylation in dimethylformamide (DMF) in the presence of aldehydes to form nucleophilic trichloromethyl anion, which then adds to the aldehydes to form trichloromethyl carbinols. It can also undergo thermal decarboxylation in aprotonic solvents in the presence of olefins to generate dichlorocarbene as an intermediate.
Understanding the link between community diversity and ecosystem function is a fundamental aspect of ecology. Systematic losses in biodiversity are widely acknowledged but the impact this may exert on ecosystem functioning remains ambiguous. There is growing evidence of a positive
The thermal decarboxylation of alkali trichloroacetates in aprotic solvents. II. Decarboxylation in the presence of olefins.
The potential of various quantitative lateral flow (LF) based assays utilizing up-converting phosphor (UCP) reporters for the diagnosis of schistosomiasis is reviewed including recent developments. Active infections are demonstrated by screening for the presence of regurgitated worm antigens (genus specific
Journal of neural transmission (Vienna, Austria : 1996), 122(1), 35-42 (2014-07-23)
The cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of most antidepressants. Comedication with a potent CYP2D6 inhibitor can convert patients with extensive metabolizer (EM) or ultra-rapid metabolizer (UM) genotypes into poor metabolizer (PM) phenotypes. Since comedication is frequent