MilliporeSigma
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122564

Sigma-Aldrich

Mechlorethamine hydrochloride

98%

Synonym(s):
MBA hydrochloride, N-Methylbis(2-chloroethyl)amine hydrochloride, Bis(2-chloroethyl)methylamine, Bis(2-Chloroethyl)methylamine, Nitrogen mustard, NM, 2-Chloro-N-(2-chloroethyl)-N-methylethanamine
Linear Formula:
(ClCH2CH2)2NCH3·HCl
CAS Number:
Molecular Weight:
192.51
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

98%

form

solid

mp

108-111 °C (lit.)

solubility

H2O: very soluble
alcohol: soluble

SMILES string

Cl.CN(CCCl)CCCl

InChI

1S/C5H11Cl2N.ClH/c1-8(4-2-6)5-3-7;/h2-5H2,1H3;1H

InChI key

QZIQJVCYUQZDIR-UHFFFAOYSA-N

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Application

Mechlorethamine hydrochloride was used in a fluorescence-based apurinic/apyrimidinic site cleavage assay for the identification of apurinic/apyrimidinic endonuclease inhibitors in human cells. It was used in a study to demonstrate the effect of povidone iodine ointment against skin toxicity caused by sulphur and nitrogen mustard.

Packaging

5, 25 g in glass bottle

Biochem/physiol Actions

Mechlorethamine hydrochloride administration reduces the tensile strength of the abdominal wounds in rats.

Signal Word

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Oral - Carc. 1B - Eye Dam. 1 - Muta. 1B - Repr. 1B - Skin Corr. 1B

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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